low density lipoprotein (MedChemExpress)

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MedChemExpress low density lipoprotein
Low Density Lipoprotein, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-np012/Low+density+lipoprotein/pmc08178257-32-37-35
Average 94 stars, based on 12 article reviews

low density lipoprotein - by Bioz Stars, 2026-10

94/100 stars

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Membrane:

Article Title: Uncovering the mechanism of Buyang Huanwu Decoction in regulating mitochondrial dysfunction to alleviate atherosclerosis: BTK, PREPL, and P2RX7 proteins play key roles.
Article Snippet: The purpose of this study was to uncover key target proteins and corresponding active ingredients of Buxue Huanwu Decoction (BYHWD) on improving mitochondrial function to alleviate atherosclerosis (AS) via construction of a novel strategy based on in silico virtual screening, UHPLC-Q-TOF-MS/MS, and experimental verification.. Firstly, 57 compounds of BYHWD were identified using UHPLC-Q-TOF-MS/MS technology, followed by the selection of 13 candidate compounds using Druggability predictions.. Subsequently, a combination of differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA), and machine learning methods were employed to identify three hub genes associated with mitochondrial function and AS, including BTK, P2RX7 and PREPL.

Cell Culture:

Article Title: Inhibition of LXR Signaling in Human Foam Cells Impairs Macrophage-to-Endothelial Cell Cross Talk and Promotes Endothelial Cell Inflammation
Article Snippet: Human monocytes were differentiated into macrophages for 6 days with 50 ng/mL of M-CSF (CSF1 [colony-stimulating factor 1]; Miltenyi Biotec; catalog No. 130-093-963) into RPMI (Roswell Park Memorial Institute) 1640 medium (GIBCO; Fisher Scientific, Strasbourg, France) supplemented with 10% fetal bovine serum in 5% CO 2 and 37 °C. .. On day 6, hMDMs were treated for 48 hours with 1 of the following treatments: whole atherosclerotic plaque extracts (1% v/v in cell culture medium), 10 μmol/L 27-hydroxycholesterol (27OHC; Avanti Polar Lipids; Sigma; France; catalog No. 20380-11-4), or 50 μg/mL oxidized low-density lipoprotein, with or without LXR antagonist: 1 μmol/L of GSK (Sigma-Aldrich, St. Louis, MO; catalog No. 1221277-90-2) or 10 μmol/L of SR9238 (MedChemExpress, Monmouth Junction, NJ; catalog No. HY-101442). .. A vehicle control, dimethylsulfoxyde (Sigma-Aldrich; catalog No. D8418), was consistently included for comparison.

Article Title: Inhibition of LXR Signaling in Human Foam Cells Impairs Macrophage-to-Endothelial Cell Cross Talk and Promotes Endothelial Cell Inflammation
Article Snippet: 910 June 2025 Arterioscler Thromb Vasc Biol.. 2025;45:910–927.. DOI: 10.1161/ATVBAHA.125.322448 Arterioscler Thromb Vasc Biol is available at www.ahajournals.org/journal/atvb Correspondence to: David Masson, PharmD, PhD, Université Bourgogne Europe, UMR1231, UFR des Sciences de Santé – bureau R26, 7 boulevard Jeanne d’Arc, 21000 Dijon, France, Email david.masson@chu-dijon.fr; or Damien Leleu, PharmD, PhD, Université Bourgogne Europe UMR1231, UFR des Sciences de Santé – bureau R26, 7 boulevard Jeanne d’Arc, 21000 Dijon, France, Email damien.leleu@u-bourgogne.fr Supplemental Material is available at https://www.ahajournals.org/doi/suppl/10.1161/ATVBAHA.125.322448.

Cholesterol Assay:

Article Title: Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy
Article Snippet: Notoginsenoside R1 (NGR1, chemical structure C 47 H 80 O 18 , molecular weight = 933 g/mol, purity = 99.5%, BD2143) and saikosaponin B2 (SSB2, chemical structure C 42 H 68 O 13 , molecular weight = 781 g/mol, purity = 99.5%, BD150742 ) were purchased from bidepharm(Shanghai,China). .. Additionally, the following reagents were purchased:Oxidized low-density lipoprotein (ox-LDL, YB-002, Yiyuan Biotech, China), Rapamycin (HY-10219, MCE, USA), Ultra-sensitive ECL chemiluminescence kit (M2301, HaiGene, China), Reactive Oxygen Species Assay Kit(S0033S, Beyotime, China),Oil Red O (O8010, Solarbio, China), total cholesterol assay kit (A111-1–1, njjcnio, China), triglyceride assay kit (A110-1–1, njjcbio, China), high-density lipoprotein cholesterol assay kit (A112-1–1, njjcbio, China), low-density lipoprotein cholesterol assay kit (A113-1–1, njjcbio, China), creatinine assay kit (C011-2–1, njjcbio, China), aspartate aminotransferase assay kit (C010-2–1, njjcbio, China), alanine aminotransferase assay kit (C009-2–1, njjcbio, China). .. 30 Male ApoE -/- mice at 7 weeks of age were obtained from the Animal Experimental Center of North Sichuan Medical College (Sichuan, China).

Article Title: Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Article Snippet: Notoginsenoside R1 (NGR1, chemical structure C 47 H 80 O 18 , molecular weight = 933 g/mol, purity = 99.5%, BD2143) and saikosaponin B2 (SSB2, chemical structure C 42 H 68 O 13 , molecular weight = 781 g/mol, purity = 99.5%, BD150742) were purchased from bidepharm(Shanghai,China). .. Additionally, the following reagents were purchased:Oxidized low-density lipoprotein (ox-LDL, YB-002, Yiyuan Biotech, China), Rapamycin (HY-10219, MCE, USA), Ultra-sensitive ECL chemiluminescence kit (M2301, HaiGene, China), Reactive Oxygen Species Assay Kit(S0033S, Beyotime, China),Oil Red O (O8010, Solarbio, China), total cholesterol assay kit (A111-1–1, njjcnio, China), triglyceride assay kit (A110-1–1, njjcbio, PLOS One | https://doi.org/10.1371/journal.pone.0326687 June 27, 2025 4 / 23 China), high-density lipoprotein cholesterol assay kit (A112-1–1, njjcbio, China), low-density lipoprotein cholesterol assay kit (A113-1–1, njjcbio, China), creatinine assay kit (C011-2–1, njjcbio, China), aspartate aminotransferase assay kit (C0102–1, njjcbio, China), alanine aminotransferase assay kit (C009-2–1, njjcbio, China). .. 30 Male ApoE-/- mice at 7 weeks of age were obtained from the Animal Experimental Center of North Sichuan Medical College (Sichuan, China).

Recombinant:

Article Title: Integrated Transcriptomic and Functional Analyses Reveal lncRNA-miRNA-mRNA Axis in AML Relapse After Allo-HSCT.
Article Snippet: .. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C om m ons L icense 3Cancer Science, 2026 SFEM II (StemCell#09605), or IMDM (Gibco#12440053), supplemented as indicated with recombinant human cytokines and additives, including SCF (StemCell #78062), FLT3L (Miltenyi#130–096- 474), TPO (StemCell #78210.1), IL- 6 (MCE# HY- P7044), IL- 3 (MCE# HY- P70576), G- CSF (MCE# HY- P73523), LDL (MCE# HY- NP012), hydrocortisone sodium hemisuccinate (Sigma#H2270), and FBS (Gibco# A5669701). ..

Article Title: Integrated Transcriptomic and Functional Analyses Reveal lncRNA ‐ miRNA ‐ mRNA Axis in AML Relapse After Allo‐ HSCT
Article Snippet: CD34 + cells were magnetically isolated using CD34 MicroBeads with MS/LS columns on a magnetic separator in PBS containing 0.5% BSA and 2 mM EDTA. .. Cells were maintained in one of the following media: MyeloCult H5100 (StemCell#05150), StemSpan SFEM II (StemCell#09605), or IMDM (Gibco#12440053), supplemented as indicated with recombinant human cytokines and additives, including SCF (StemCell #78062), FLT3L (Miltenyi#130–096‐474), TPO (StemCell #78210.1), IL‐6 (MCE# HY‐P7044), IL‐3 (MCE# HY‐ P70576 ), G‐CSF (MCE# HY‐ P73523 ), LDL (MCE# HY‐NP012), hydrocortisone sodium hemisuccinate (Sigma#H2270), and FBS (Gibco# A5669701). ..

Clinical Proteomics:

Concentration Assay:

Article Title: Multi-Omics Analysis Combined with Machine Learning Identified FABP4 in Smooth Muscle Cells as a Pathogenic Factor in Atherosclerosis
Article Snippet: .. Murine aortic vascular smooth muscle cells (MOVAS) (ATCC, No. CRL-2797 TM ) were treated with a 25 μg/mL concentration of oxidized low-density lipoprotein (ox-LDL) (Yiyuan Biotechnologies, Guangzhou, China, No. YB-002-1) and 0.2 μM (S)-RP-6306 (MedChemExpress, China, No. HY-145817A) for a duration of 4 days. ..

Review