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mel c a1 group  (MedChemExpress)


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    Structured Review

    MedChemExpress mel c a1 group
    Mel C A1 Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n7452/Coumermycin+A1/pm41557248-61-3-17
    Average 95 stars, based on 34 article reviews
    mel c a1 group - by Bioz Stars, 2026-10
    95/100 stars

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    Related Articles

    other:

    Article Title: Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2/STAT3 and Nrf2/HO-1 pathways
    Article Snippet: According to the literature, the dosage of ML385 (Cat. No. B8300, APExBIO, Houston, Texas, USA) is 30 mg/kg [ ], and the dosage of Coumermycin A1(Cat. No. HY-N7452, MedChemExpress, New Jersey, USA) is 100 μg/kg [ ].

    Article Title: Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2/STAT3 and Nrf2/HO-1 pathways.
    Article Snippet: According to the literature, the dosage of ML385 (Cat. No. B8300, APExBIO, Houston, Texas, USA) is 30 mg/kg(26), and the dosage of Coumermycin A1(Cat. No. HY-N7452, MedChemExpress, New Jersey, USA) is 100μg/kg(27).

    Activation Assay:

    Article Title: MiR-135b-5p relieves sevoflurane-induced postoperative cognitive dysfunction by inhibiting JAK2-STAT3-mediated hepcidin upregulation.
    Article Snippet: .. To further evaluate the involvement of the JAK2–STAT3 signaling pathway, the Sevo.3 Day +miRNA + Coumermycin A1 group received intraperitoneal administration of the JAK2 agonist Coumermycin A1 (100 μg/kg, Cat# 4434–05–3, MedChemExpress LLC, Shanghai, China) prior to sevoflurane exposure (Zhang et al., 2024c), establishing a pharmacological activation model of JAK2–STAT3 signaling. ..

    Mouse Assay:

    Article Title: Adipocyte fatty acid-binding protein as a cerebrospinal fluid-accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation.
    Article Snippet: .. Mice were gavaged orally with a selective A-FABP inhibitor (BMS309403, #HY-101903, MCE, USA; 15 mg/kg/day; dissolved in 4% Tween 80 and phosphatebuffered saline) or vehicle (without BMS309403) one and 12 h after the sham or SAH surgery and then once per day for the next six consecutive days (concentration as previously described).11 JAK2 activator coumermycin A1 (C-A1, #HY-N7452, 100 μg/kg; MCE, USA) was administered intraperitoneally for 1 h after SAH. .. Mice were anaesthetized with 2% isoflurane (Matrx, #VMR) delivered via a calibrated nose cone vaporizer.

    Saline:

    Article Title: Adipocyte fatty acid-binding protein as a cerebrospinal fluid-accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation.
    Article Snippet: .. Mice were gavaged orally with a selective A-FABP inhibitor (BMS309403, #HY-101903, MCE, USA; 15 mg/kg/day; dissolved in 4% Tween 80 and phosphatebuffered saline) or vehicle (without BMS309403) one and 12 h after the sham or SAH surgery and then once per day for the next six consecutive days (concentration as previously described).11 JAK2 activator coumermycin A1 (C-A1, #HY-N7452, 100 μg/kg; MCE, USA) was administered intraperitoneally for 1 h after SAH. .. Mice were anaesthetized with 2% isoflurane (Matrx, #VMR) delivered via a calibrated nose cone vaporizer.

    Concentration Assay:

    Article Title: Adipocyte fatty acid-binding protein as a cerebrospinal fluid-accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation.
    Article Snippet: .. Mice were gavaged orally with a selective A-FABP inhibitor (BMS309403, #HY-101903, MCE, USA; 15 mg/kg/day; dissolved in 4% Tween 80 and phosphatebuffered saline) or vehicle (without BMS309403) one and 12 h after the sham or SAH surgery and then once per day for the next six consecutive days (concentration as previously described).11 JAK2 activator coumermycin A1 (C-A1, #HY-N7452, 100 μg/kg; MCE, USA) was administered intraperitoneally for 1 h after SAH. .. Mice were anaesthetized with 2% isoflurane (Matrx, #VMR) delivered via a calibrated nose cone vaporizer.

    Control:

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway
    Article Snippet: .. Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group. ..



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    Fatty acid‐binding protein (A‐FABP) mediates neuroinflammation via the <t>JAK2/STAT3</t> signalling pathway. (A) Workflow diagram. Proteomic analysis of brain tissue around the subarachnoid space from the subarachnoid haemorrhage (SAH)‐treated Veh group and the SAH‐treated BMS group ( n = 4). (B) KEGG enrichment highlights the JAK‐STAT signalling pathway. (C) Volcano plot demonstrates the results of 85 differentially expressed proteins. STAT3 is labelled in green. (D–H) Representative western blot images and quantitative analyses of (E) p‐STAT3/STAT3, (F) p‐JAK1/JAK1, (G) p‐JAK2/JAK2 and (H) p‐JAK3/JAK3 in WT and knockout (KO) mice after SAH. (I–L) Representative western blot images and quantitative analyses of (J) TNF‐α, (K) IL‐1β and (L) IL‐6 in different groups. (M and N) Representative images and quantitative analysis of TUNEL staining with co‐staining with NeuN (red) and TUNEL‐positive neurons (green, scale bar = 100 µm, n = 6). Data are presented as means ± SD. * p < .05, ** p < .01, *** p < .001. C‐A1, coumermycin A1; ns, no significance. Source : Schematic diagram created with BioRender.com.
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    <t>PCPTF</t> improved the function and pathological changes of liver cancer mice. (A) Measurement of body weight of mice with liver cancer. (B) Tumor volume change. (C) Measurement of tumor weight. (D) HE staining was used to detect the pathological characteristics of tumor tissue in mice (400×). Scale bar =50 µm. (E,F) Tumor cell proliferation was detected by immunohistochemistry (400×). Scale bar =50 µm. (G,H) TUNEL was applied to detect apoptosis of tumor cells (400×). Scale bar =50 µm. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. H, high-dose; HE, hematoxylin and eosin; L, low-dose; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.
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    mel c a1 group  (MedChemExpress)
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    <t>PCPTF</t> improved the function and pathological changes of liver cancer mice. (A) Measurement of body weight of mice with liver cancer. (B) Tumor volume change. (C) Measurement of tumor weight. (D) HE staining was used to detect the pathological characteristics of tumor tissue in mice (400×). Scale bar =50 µm. (E,F) Tumor cell proliferation was detected by immunohistochemistry (400×). Scale bar =50 µm. (G,H) TUNEL was applied to detect apoptosis of tumor cells (400×). Scale bar =50 µm. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. H, high-dose; HE, hematoxylin and eosin; L, low-dose; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.
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    Image Search Results


    Fatty acid‐binding protein (A‐FABP) mediates neuroinflammation via the JAK2/STAT3 signalling pathway. (A) Workflow diagram. Proteomic analysis of brain tissue around the subarachnoid space from the subarachnoid haemorrhage (SAH)‐treated Veh group and the SAH‐treated BMS group ( n = 4). (B) KEGG enrichment highlights the JAK‐STAT signalling pathway. (C) Volcano plot demonstrates the results of 85 differentially expressed proteins. STAT3 is labelled in green. (D–H) Representative western blot images and quantitative analyses of (E) p‐STAT3/STAT3, (F) p‐JAK1/JAK1, (G) p‐JAK2/JAK2 and (H) p‐JAK3/JAK3 in WT and knockout (KO) mice after SAH. (I–L) Representative western blot images and quantitative analyses of (J) TNF‐α, (K) IL‐1β and (L) IL‐6 in different groups. (M and N) Representative images and quantitative analysis of TUNEL staining with co‐staining with NeuN (red) and TUNEL‐positive neurons (green, scale bar = 100 µm, n = 6). Data are presented as means ± SD. * p < .05, ** p < .01, *** p < .001. C‐A1, coumermycin A1; ns, no significance. Source : Schematic diagram created with BioRender.com.

    Journal: Clinical and Translational Medicine

    Article Title: Adipocyte fatty acid‐binding protein as a cerebrospinal fluid–accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation

    doi: 10.1002/ctm2.70607

    Figure Lengend Snippet: Fatty acid‐binding protein (A‐FABP) mediates neuroinflammation via the JAK2/STAT3 signalling pathway. (A) Workflow diagram. Proteomic analysis of brain tissue around the subarachnoid space from the subarachnoid haemorrhage (SAH)‐treated Veh group and the SAH‐treated BMS group ( n = 4). (B) KEGG enrichment highlights the JAK‐STAT signalling pathway. (C) Volcano plot demonstrates the results of 85 differentially expressed proteins. STAT3 is labelled in green. (D–H) Representative western blot images and quantitative analyses of (E) p‐STAT3/STAT3, (F) p‐JAK1/JAK1, (G) p‐JAK2/JAK2 and (H) p‐JAK3/JAK3 in WT and knockout (KO) mice after SAH. (I–L) Representative western blot images and quantitative analyses of (J) TNF‐α, (K) IL‐1β and (L) IL‐6 in different groups. (M and N) Representative images and quantitative analysis of TUNEL staining with co‐staining with NeuN (red) and TUNEL‐positive neurons (green, scale bar = 100 µm, n = 6). Data are presented as means ± SD. * p < .05, ** p < .01, *** p < .001. C‐A1, coumermycin A1; ns, no significance. Source : Schematic diagram created with BioRender.com.

    Article Snippet: JAK2 activator coumermycin A1 (C‐A1, #HY‐N7452, 100 μg/kg; MCE, USA) was administered intraperitoneally for 1 h after SAH.

    Techniques: Binding Assay, Western Blot, Knock-Out, TUNEL Assay, Staining

    PCPTF improved the function and pathological changes of liver cancer mice. (A) Measurement of body weight of mice with liver cancer. (B) Tumor volume change. (C) Measurement of tumor weight. (D) HE staining was used to detect the pathological characteristics of tumor tissue in mice (400×). Scale bar =50 µm. (E,F) Tumor cell proliferation was detected by immunohistochemistry (400×). Scale bar =50 µm. (G,H) TUNEL was applied to detect apoptosis of tumor cells (400×). Scale bar =50 µm. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. H, high-dose; HE, hematoxylin and eosin; L, low-dose; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.

    Journal: Translational Cancer Research

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway

    doi: 10.21037/tcr-2025-1525

    Figure Lengend Snippet: PCPTF improved the function and pathological changes of liver cancer mice. (A) Measurement of body weight of mice with liver cancer. (B) Tumor volume change. (C) Measurement of tumor weight. (D) HE staining was used to detect the pathological characteristics of tumor tissue in mice (400×). Scale bar =50 µm. (E,F) Tumor cell proliferation was detected by immunohistochemistry (400×). Scale bar =50 µm. (G,H) TUNEL was applied to detect apoptosis of tumor cells (400×). Scale bar =50 µm. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. H, high-dose; HE, hematoxylin and eosin; L, low-dose; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.

    Article Snippet: Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group.

    Techniques: Staining, Immunohistochemistry, TUNEL Assay, End Labeling

    PCPTF regulated inflammatory factors, oxidative stress, and protein levels in mice. (A-C) Serum levels of inflammatory factors IL-1β, TNF-α, and IL-6 were detected by ELISA. (D-F) The contents of SOD, MDA, and ROS in serum of mice were detected. (G-I) The expressions of JAK2, STAT3, p-JAK2, and p-STAT3 proteins in tumor tissues were determined by western blot. β-actin was the internal parameter. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. ELISA, enzyme-linked immunosorbent assay; H, high-dose; IL-1β, interleukin-1β; IL-6, interleukin-6; JAK2, Janus kinase 2; L, low-dose; MDA, malondialdehyde; p-, phospho-; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-α.

    Journal: Translational Cancer Research

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway

    doi: 10.21037/tcr-2025-1525

    Figure Lengend Snippet: PCPTF regulated inflammatory factors, oxidative stress, and protein levels in mice. (A-C) Serum levels of inflammatory factors IL-1β, TNF-α, and IL-6 were detected by ELISA. (D-F) The contents of SOD, MDA, and ROS in serum of mice were detected. (G-I) The expressions of JAK2, STAT3, p-JAK2, and p-STAT3 proteins in tumor tissues were determined by western blot. β-actin was the internal parameter. Each group had six mice. *, P<0.05; **, P<0.01; ***, P<0.001 vs . model. ELISA, enzyme-linked immunosorbent assay; H, high-dose; IL-1β, interleukin-1β; IL-6, interleukin-6; JAK2, Janus kinase 2; L, low-dose; MDA, malondialdehyde; p-, phospho-; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-α.

    Article Snippet: Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group.

    Techniques: Enzyme-linked Immunosorbent Assay, Western Blot

    Western blot assay. (A-C) The expressions of p-JAK2, JAK2, p-STAT3, and STAT3 proteins in hepatocellular carcinoma cells were measured by western blot. β-actin was the internal parameter. The experiment was repeated three times. ^, P<0.05; ^^, P<0.01 vs . control. ### , P<0.001 vs . LPS. ++ , P<0.01 vs . LPS + PCPTF. CA1, coumermycin A1; JAK2, Janus kinase 2; LPS, lipopolysaccharides; p-, phospho-; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; STAT3, signal transducer and activator of transcription 3.

    Journal: Translational Cancer Research

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway

    doi: 10.21037/tcr-2025-1525

    Figure Lengend Snippet: Western blot assay. (A-C) The expressions of p-JAK2, JAK2, p-STAT3, and STAT3 proteins in hepatocellular carcinoma cells were measured by western blot. β-actin was the internal parameter. The experiment was repeated three times. ^, P<0.05; ^^, P<0.01 vs . control. ### , P<0.001 vs . LPS. ++ , P<0.01 vs . LPS + PCPTF. CA1, coumermycin A1; JAK2, Janus kinase 2; LPS, lipopolysaccharides; p-, phospho-; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; STAT3, signal transducer and activator of transcription 3.

    Article Snippet: Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group.

    Techniques: Western Blot, Control

    Effect of PCPTF on human hepatocellular carcinoma cells stimulated by LPS. (A,B) Colony formation was performed to examine the proliferation of liver cancer cells (stained with Giemsa dyeing solution). (C-E) The contents of inflammatory factors IL-1β, TNF-α, and IL-6 were detected by ELISA. (F-H) The contents of SOD, MDA, and ROS were measured. All experiments were repeated three times. ^^, P<0.01; ^^^, P<0.001 vs . control. ## , P<0.01; ### , P<0.001 vs . LPS. + , P<0.05; ++ , P<0.01; +++ , P<0.001 vs . LPS + PCPTF. CA1, coumermycin A1; ELISA, enzyme-linked immunosorbent assay; IL-1β, interleukin-1β; IL-6, interleukin-6; LPS, lipopolysaccharides; MDA, malondialdehyde; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase; TNF-α, tumor necrosis factor-α.

    Journal: Translational Cancer Research

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway

    doi: 10.21037/tcr-2025-1525

    Figure Lengend Snippet: Effect of PCPTF on human hepatocellular carcinoma cells stimulated by LPS. (A,B) Colony formation was performed to examine the proliferation of liver cancer cells (stained with Giemsa dyeing solution). (C-E) The contents of inflammatory factors IL-1β, TNF-α, and IL-6 were detected by ELISA. (F-H) The contents of SOD, MDA, and ROS were measured. All experiments were repeated three times. ^^, P<0.01; ^^^, P<0.001 vs . control. ## , P<0.01; ### , P<0.001 vs . LPS. + , P<0.05; ++ , P<0.01; +++ , P<0.001 vs . LPS + PCPTF. CA1, coumermycin A1; ELISA, enzyme-linked immunosorbent assay; IL-1β, interleukin-1β; IL-6, interleukin-6; LPS, lipopolysaccharides; MDA, malondialdehyde; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; RNS, reactive nitrogen species; ROS, reactive oxygen species; SOD, superoxide dismutase; TNF-α, tumor necrosis factor-α.

    Article Snippet: Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group.

    Techniques: Staining, Enzyme-linked Immunosorbent Assay, Control

    Effects of PCPTF on the downstream genes related to the JAK2/STAT3 pathway and apoptosis protein in LPS-stimulated human hepatocellular carcinoma cells. (A-E) The expressions of cyclin D1, VEGFA, Bcl-2, and Bax in hepatocellular carcinoma cells were measured by western blot. β-actin was the internal parameter. The experiment was repeated three times. ^^, P<0.01; ^^^, P<0.001 vs . control. ### , P<0.001 vs . LPS. +++ , P<0.001 vs . LPS + PCPTF. CA1, coumermycin A1; JAK2, Janus kinase 2; LPS, lipopolysaccharides; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; STAT3, signal transducer and activator of transcription 3; VEGFA, vascular endothelial growth factor A.

    Journal: Translational Cancer Research

    Article Title: Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway

    doi: 10.21037/tcr-2025-1525

    Figure Lengend Snippet: Effects of PCPTF on the downstream genes related to the JAK2/STAT3 pathway and apoptosis protein in LPS-stimulated human hepatocellular carcinoma cells. (A-E) The expressions of cyclin D1, VEGFA, Bcl-2, and Bax in hepatocellular carcinoma cells were measured by western blot. β-actin was the internal parameter. The experiment was repeated three times. ^^, P<0.01; ^^^, P<0.001 vs . control. ### , P<0.001 vs . LPS. +++ , P<0.001 vs . LPS + PCPTF. CA1, coumermycin A1; JAK2, Janus kinase 2; LPS, lipopolysaccharides; PCPTF, total flavonoids extracted from Penthorum chinense Pursh ; STAT3, signal transducer and activator of transcription 3; VEGFA, vascular endothelial growth factor A.

    Article Snippet: Later, the cells were divided into the control group, LPS (ST1470, Beyotime) group, LPS + PCPTF group, and LPS + PCPTF + coumermycin A1 (CA1; HY-N7452, MCE, Princeton, NJ, USA) group.

    Techniques: Western Blot, Control