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tubuloside a  (MedChemExpress)


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    Structured Review

    MedChemExpress tubuloside a
    CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.
    Tubuloside A, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n2155/Tubuloside+A/pmc13178040-37-8-15
    Average 94 stars, based on 3 article reviews
    tubuloside a - by Bioz Stars, 2026-10
    94/100 stars

    Images

    1) Product Images from "Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover"

    Article Title: Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover

    Journal: Renal Failure

    doi: 10.1080/0886022X.2026.2670806

    CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.
    Figure Legend Snippet: CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.

    Techniques Used: Expressing, Fluorescence, Staining, Western Blot, Solvent

    Related Articles

    Ligation:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Injection:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Expressing:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Fluorescence:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Staining:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Western Blot:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.

    Solvent:

    Article Title: P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA.
    Article Snippet: Colorectal cancer (CRC) is a malignancy with high global incidence and mortality rates, posing a serious threat to human health.. Despite favorable outcomes following early detection and surgical intervention, the asymptomatic nature of CRC often results in delayed diagnoses, limiting surgical treatment options.. Furthermore, effective therapeutic drugs for CRC remain lacking in clinical practice, highlighting an urgent need to identify novel therapeutic targets.



    Similar Products

    tubuloside a  (MedChemExpress)
    94
    MedChemExpress tubuloside a
    CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.
    Tubuloside A, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n2155/Tubuloside+A/pmc13178040-37-8-15
    Average 94 stars, based on 1 article reviews
    tubuloside a - by Bioz Stars, 2026-10
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.

    Journal: Renal Failure

    Article Title: Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover

    doi: 10.1080/0886022X.2026.2670806

    Figure Lengend Snippet: CA upregulated PLIN5 expression and ameliorated renal injury and lipid accumulation in db/db mice. (A) Schematic workflow of the docking-based virtual screening for natural product candidates targeting PLIN5 protein. (B) Chemical structure formula of five candidate products (tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside) in 2D conformer. (C) Relative fluorescence intensity of BODIPY among different treatment groups ( n = 3). (D) ORO staining among different treatment groups ( n = 3). (E) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 3). (F) Mice were treated daily by oral gavage with CA (10 mg/kg) or the solvent vehicle for 3 weeks and were sacrificed at 20 weeks. (G) Body weight of different groups of mice at week 20. (H) Blood glucose of different groups of mice at week 20. (I) Urinary albumin-to-creatinine ratio (UACR) in different groups of mice. (J) Representative periodic acid–Schiff (PAS) and quantified glomerular sclerosis index staining in glomerulus from renal tissues ( n = 6). (K) Representative BODIPY staining in glomerulus from renal tissues ( n = 6). (L) Western blot assay showing expression of PLIN5 among different treatment groups and quantitative analyses ( n = 6). (M) Representative images and quantification of PLIN5 (red), WT1 (green), and DAPI (blue)-immunofluorescent stained in glomeruli from renal tissues ( n = 6). ns: not significant ( p > 0.05), * p < 0.05, ** p < 0.01, and *** p < 0.001. Five visual fields for each section analyzed.

    Article Snippet: 1,2-Dilauroyl-sn-glycerol-3-phosphocholine (DLPC), tetragalloylglucose, cistanoside A, chebulinic acid (CA), tubuloside A, and poliumoside were purchased from MedChemExpress (Shanghai, China), dissolved in glycolic acid (GC) at 23 °C, and kept at −20 °C.

    Techniques: Expressing, Fluorescence, Staining, Western Blot, Solvent