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higenamine hydrochloride (MedChemExpress)

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MedChemExpress higenamine hydrochloride
Higenamine Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n2037a/Higenamine+hydrochloride/pm41796714-53-8-18
Average 94 stars, based on 6 article reviews

higenamine hydrochloride - by Bioz Stars, 2026-10

94/100 stars

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Article Title: In Vitro Activation of Human Adrenergic Receptors and Trace Amine-Associated Receptor 1 by Phenethylamine Analogues Present in Food Supplements
Article Snippet: Probenecid (purity ≥ 98%), adrenaline bitartrate, beta-methylphenethylamine (99%), phenethylamine (99.7%), tyramine hydrochloride (≥98%), halostachine (99%), hordenine (≥97.5%), p -octopamine (≥95%), dimethylbutylamine (98%), dimethylhexylamine (99%), dimethylaminoethanol (99.8%), puromycin dihydrochloride (10 mg/mL solution in mQ) and L-ascorbic acid (99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA). p -synephrine hydrochloride (99.6%) and higenamine hydrochloride (98.98%) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Article Title: Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments.
Article Snippet: Synephrine hydrochloride (99.6%) and higenamine hydrochloride (98.98%) were purchased from MedChemExpress (Monmouth Junction, USA).

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Article Title: Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction
Article Snippet: .. To detect the cell viability, BV-2 cells (3000 cells/well in 96-well plate) were divided four groups, Control group (normal cultivation), lipopolysaccharide (LPS) group (treated with LPS), LPS + DMSO group (treated with LPS and dimethyl sulfoxide (DMSO)), and LPS + norcoclaurine (treated with 200 ng/ mL LPS (L2880, Sigma, St. Louis, MO, USA) and norcoclaurine (HY-N2037A, Med Chem Express, Shanghai, China). .. After treatment for 24 h, 10% Cell Counting Kit-8 (CCK-8) regent (BS350B, Biosharp) was added to each well and continue to cultivate for 2 h. The values were obtained at the 450 nm.

Article Title: Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction
Article Snippet: .. To detect the cell viability, BV-2 cells (3000 cells/well in 96-well plate) were divided four groups, Control group (normal cultivation), lipopolysaccharide (LPS) group (treated with LPS), LPS + DMSO group (treated with LPS and dimethyl sulfoxide (DMSO)), and LPS + norcoclaurine (treated with 200 ng/mL LPS (L2880, Sigma, St. Louis, MO, USA) and norcoclaurine (HY-N2037A, Med Chem Express, Shanghai, China). .. After treatment for 24 h, 10% Cell Counting Kit-8 (CCK-8) regent (BS350B, Biosharp) was added to each well and continue to cultivate for 2 h. The values were obtained at the 450 nm.

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The acquisition of active ingredients of shenfu injection and the molecular docking analysis of the active ingredients of shenfu injection and the targets NLRP3 and Caspase 1. ( A ) Cytoscape3.7.0 was applied to visualize the interaction between the active components of shenfu injection and the targets NLRP3 and Caspase 1, and to construct the compound-ingredient-target diagram. ( B and C ) PyMOL 2.5.4 was utilized to visualize the molecular docking results of (R)-norcoclaurine with NLRP3 ( B ) and ignavine with Caspase 1 ( C ). NLRP3, nucleotide binding oligomerization domain-like receptor family pyrin domain protein 3.

Journal: Journal of Inflammation Research

Article Title: Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction

doi: 10.2147/JIR.S481171

Figure Lengend Snippet: The acquisition of active ingredients of shenfu injection and the molecular docking analysis of the active ingredients of shenfu injection and the targets NLRP3 and Caspase 1. ( A ) Cytoscape3.7.0 was applied to visualize the interaction between the active components of shenfu injection and the targets NLRP3 and Caspase 1, and to construct the compound-ingredient-target diagram. ( B and C ) PyMOL 2.5.4 was utilized to visualize the molecular docking results of (R)-norcoclaurine with NLRP3 ( B ) and ignavine with Caspase 1 ( C ). NLRP3, nucleotide binding oligomerization domain-like receptor family pyrin domain protein 3.

Article Snippet: To detect the cell viability, BV-2 cells (3000 cells/well in 96-well plate) were divided four groups, Control group (normal cultivation), lipopolysaccharide (LPS) group (treated with LPS), LPS + DMSO group (treated with LPS and dimethyl sulfoxide (DMSO)), and LPS + norcoclaurine (treated with 200 ng/mL LPS (L2880, Sigma, St. Louis, MO, USA) and norcoclaurine (HY-N2037A, Med Chem Express, Shanghai, China).

Techniques: Injection, Construct, Binding Assay

Norcoclaurine increases the cell viability and decreases inflammation and apoptosis. BV-2 cells were treated with/without LPS/norcoclaurine for 24 h. ( A ) Cell viability detection using Cell Counting Kit-8. ( B ) Western blot analysis of Caspase 1, NLRP3, IL-18, and IL-1β levels. ( C ) The relative density analysis of ( B ). *P < 0.05, **P < 0.01, ***P < 0.001.