stat3 inhibitor cucurbitacin i (MedChemExpress)
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stat3 inhibitor cucurbitacin i
Stat3 Inhibitor Cucurbitacin I, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 20 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1405/Cucurbitacin+I/pm37461040-57-26-32
Average 94 stars, based on 20 article reviews
Stat3 Inhibitor Cucurbitacin I, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 20 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1405/Cucurbitacin+I/pm37461040-57-26-32
Average 94 stars, based on 20 article reviews
stat3 inhibitor cucurbitacin i - by Bioz Stars,
2026-10
94/100 stars
Images
1) Product Images from "LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection."
Article Title: LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
Journal: Parasites & vectors
doi: 10.1186/s13071-023-05856-4
Figure Legend Snippet: Fig. 2 LILRB4 expression level on dMDSCs was regulated by p-STAT-3 during T. gondii infection. a Analysis of the expression of STAT3 and p-STAT3S727 in human dMDSCs with or without T. gondii infection. b Results of p-STAT3 expression in mouse dMDSCs of the uninfected and infected WT mice were detected by flow cytometry. c Expression levels of STAT3, p-STAT3S727 and LILRB4 in human dMDSCs treated with or without STAT3i during T. gondii infection were detected by Western blot. d, e Results of p-STAT3 and LILRB4 expression in mouse dMDSCs treated with or without JSI-124 during T. gondii infection were detected by flow cytometry. The data on human dMDSCs were identified by a paired t-test. The data on mouse dMDSCs were identified by the unpaired t-test. Asterisks indicate a significant difference at *p < 0.05 and **p < 0.01. FMO, fluorescence minus one; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; INF, infected; JSI-124, the inhibitor of STAT3 in vivo; LILRB4, leukocyte immunoglobulin-like receptor B4; mRNA, messenger RNA; NC, negative control; p-STAT3, phosphorylated STAT3; STAT3, signal transducer and activator of transcription 3; STAT3i, the inhibitor of STAT3 in vitro; WT, wild type.
Techniques Used: Expressing, Infection, Flow Cytometry, Western Blot, Fluorescence, In Vivo, Negative Control, In Vitro
Figure Legend Snippet: Fig. 5 Diagrammatic representation of LILRB4 downregulation induced by T. gondii infection resulting in the dysfunction of dMDSCs. The phosphorylation level of STAT3 was decreased after T. gondii infection, resulting in the downregulation of LILRB4 on dMDSCs. The decreased level of LILRB4 reduced the phosphorylation of SHP-2 and then inhibited the activity of STAT6, which in turn inhibited the expression levels of Arg-1 and IL-10 via binding to their respective promoter during T. gondii infection. Arg-1, arginase-1; ARG1, the gene for Arg-1; dMDSCs, decidual myeloid-derived suppressor cells; Ig, immunoglobulin; IL-10, interleukin-10; IL10, the gene for IL-10; ITIM, immunoreceptor tyrosine-based inhibitory motifs; LILRB4, leukocyte immunoglobulin-like receptor B4; p-SHP2, phosphorylated SHP-2; p-STAT3, phosphorylated STAT3; p-STAT6, phosphorylated STAT6; SHP-2, src-homology 2 domain-containing protein tyrosine phosphatase; STAT3, signal transducer and activator of transcription 3; STAT6, signal transducer and activator of transcription 6.
Techniques Used: Infection, Phospho-proteomics, Activity Assay, Expressing, Binding Assay, Derivative Assay
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