sodium aescinate sa (MedChemExpress)
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MedChemExpress
sodium aescinate sa
Sodium Aescinate Sa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1404/Sodium+aescinate/pm42046264-42-0-15
Average 94 stars, based on 2 article reviews
Sodium Aescinate Sa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1404/Sodium+aescinate/pm42046264-42-0-15
Average 94 stars, based on 2 article reviews
sodium aescinate sa - by Bioz Stars,
2026-10
94/100 stars
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other:Article Title: Synergistic Induction of Apoptosis by Apocytochrome C and Sodium Aescinate Is Mediated by Excessive Autophagy via the AKT-mTOR-TFEB Signaling Axis. Article Snippet: Cytochrome C (Cyt C) is a central mediator of intrinsic apoptosis, whereas its heme‐free precursor, apocytochrome C (APO‐Cyt C), competitively inhibits this process.. Sodium aescinate (SA), a natural triterpene saponin, is known to facilitate the endosomal escape of protein drugs.. We initially aimed to investigate the effects of enhancing endosomal escape efficiency on protein activity through the combination of SA and Cyt C. However, this study investigates an cytotoxicity observed when APO‐Cyt C is combined with SA and aims to elucidate the underlying molecular mechanism. High Performance Liquid Chromatography:Article Title: Engineered MAP30ER: A plant toxin-derived platform for EGFR-Targeted delivery of protein and chemotherapeutic payloads. Article Snippet: The nonspecific toxicity of traditional chemotherapeutic agents and the intracellular delivery barriers of proteinbased drugs have limited their clinical applications.. Efficient targeted delivery properties of toxin proteins themselves provide important insights into the design of novel drug delivery systems.. Inspired by the natural targeting properties of the plant-derived type I ribosome-inactivating protein (RIPs) MAP30, we engineered a detoxified carrier, MAP30ER, through site-directed mutagenesis of key enzymatic residues (E158A/R161A). |