sh sy5y cells (MedChemExpress)
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sh sy5y cells
Sh Sy5y Cells, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1370/Tanshinone+IIA+sulfonate+sodium/pmc07131914-24-1-16
Average 93 stars, based on 7 article reviews
Sh Sy5y Cells, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1370/Tanshinone+IIA+sulfonate+sodium/pmc07131914-24-1-16
Average 93 stars, based on 7 article reviews
sh sy5y cells - by Bioz Stars,
2026-10
93/100 stars
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1) Product Images from "Sodium tanshinone IIA sulfonate protects against Aβ‐induced cell toxicity through regulating Aβ process"
Article Title: Sodium tanshinone IIA sulfonate protects against Aβ‐induced cell toxicity through regulating Aβ process
Journal: Journal of Cellular and Molecular Medicine
doi: 10.1111/jcmm.15006
Figure Legend Snippet: STS protects against Aβ‐induced cell toxicity in SH‐SY5Y cells. (A) MTS cell viability assay was performed in SH‐SY5Y cells after exposure to different concentrations of Aβ (1.25, 2.5, 5, 10 and 20 µmol/L) for 24 h. (B) MTS cell viability of Aβ (10 µmol/L)‐treated SY5Y cells after STS preprotection. STS‐L: 1 µmol/L, STS‐M: 10 µmol/L, STS‐H: 100 µmol/L. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group; # P < .05, ## P < .01 vs Aβ group
Techniques Used: Viability Assay
Figure Legend Snippet: STS ameliorates oxidative and nitrosative stress in Aβ‐treated SH‐SY5Y cells. The levels of ROS (A), MDA (B), the activities of SOD (C), GSH‐Px (D) and the levels of NO (E), iNOS (F) in SH‐SY5Y cells. STS‐L: 1 µmol/L, STS‐M: 10 µmol/L, STS‐H: 100 µmol/L. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group; # P < .05, ## P < .01 vs Aβ group
Techniques Used:
Figure Legend Snippet: STS reverses neuroinflammation in Aβ‐treated SH‐SY5Y cells. The levels of IL‐1β (A), IL‐6 (B) and TNF‐α (C) were detected by ELISA in SH‐SY5Y cells. STS‐L: 1 µmol/L, STS‐M: 10 µmol/L, STS‐H: 100 µmol/L. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group; # P < .05, ## P < .01 vs Aβ group
Techniques Used: Enzyme-linked Immunosorbent Assay
Figure Legend Snippet: STS improves the protein expressions of Aβ degrading enzymes in Aβ‐treated SH‐SY5Y cells. NEP (A) and IDE (B) protein levels were detected by Western blotting in SH‐SY5Y cells. STS‐L: 1 µmol/L, STS‐M: 10 µmol/L, STS‐H: 100 µmol/L. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group; # P < .05, ## P < .01 vs Aβ group
Techniques Used: Western Blot
Figure Legend Snippet: STS decreases Aβ level in SH‐SY5Y‐APPsw cells. Aβ1‐40 (A) and Aβ1‐42 (B) levels were measured by ELISA in SH‐SY5Y‐APPsw cells. Aβ protein level was detected by Western blotting (C and D) in SH‐SY5Y‐APPsw cells. STS‐L: 1 µmol/L, STS‐M: 10 µmol/L, STS‐H: 100 µmol/L. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group
Techniques Used: Enzyme-linked Immunosorbent Assay, Western Blot
Figure Legend Snippet: STS affects Aβ generating enzymes in SH‐SY5Y‐APPsw cells. α‐ (A), β‐ (B) and γ‐secretase (C) activities were measured by ELISA in SH‐SY5Y‐APPsw cells. The mRNA expressions of ADAM 10 (D); BACE1 (E) and PS1 (F) were determined by qPCR in SH‐SY5Y‐APPsw cells. Experimental values were expressed as mean ± SEM. * P < .05, ** P < .01 vs Con group
Techniques Used: Enzyme-linked Immunosorbent Assay
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