api group (MedChemExpress)
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MedChemExpress
api group
Api Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1201/Apigenin/pmc12103689-30-11-22
Average 95 stars, based on 53 article reviews
Api Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 53 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n1201/Apigenin/pmc12103689-30-11-22
Average 95 stars, based on 53 article reviews
api group - by Bioz Stars,
2026-10
95/100 stars
Images
1) Product Images from "Apigenin Inhibits Cell Ferroptosis by Activating the PI3K/Akt Pathway and Alleviates Renal Injury Caused by Hypertension"
Article Title: Apigenin Inhibits Cell Ferroptosis by Activating the PI3K/Akt Pathway and Alleviates Renal Injury Caused by Hypertension
Journal: Dose-Response
doi: 10.1177/15593258251335814
Figure Legend Snippet: API Shows No Liver and Kidney Toxicity and Reduces Blood Pressure in Ang II-Infused Mice. (A) Chemical Structure, Molecular Weight, and Chemical Formula of API. (B) The Hepatic and Renal Tissues Were Stained With Hematoxylin and Eosin (HE) (200×). (C, D) Hepatic and Renal Function Were Evaluated by Measuring Related Indicators in Serum of Mice, including ALT, AST, Scr and BUN. (E) Systolic Blood Pressure. (F) Diastolic Blood Pressure. (G) Mean Artery Blood Pressure. Data Are Presented as Mean ± SD (n = 8 in Each Group), and Analyzed Using ANOVA. *** P < .001 vs Control Group; # P < .05, ## P < .01,, ### P < 0.001 vs Ang II Group. API, Apigenin; ALT, Alanine Transaminase; AST, Aspartate Transaminase; Scr, Serum Creatinine; BUN, Blood Urea Nitrogen; Ang II, Angiotensin II; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure, MAP, Mean Arterial Pressure.
Techniques Used: Molecular Weight, Staining, Control
Figure Legend Snippet: API Improves the Morphological Changes, Renal Hypertrophy Index and Renal Function of Ang II-Infused Mice. (A) The Renal Tissues of Mice Were Stained With HE (400×). (B) Body Weight (BW) of Mice. (C) Kidney Weight (KW) of Mice. (D) Renal Hypertrophy Index (KW/BW) of Mice. (E) Serum Creatinine (Scr). (F) Blood Urea Nitrogen (BUN). (G) Serum Cystatin C (Cys-C). Data Are Presented as Mean ± SD (n = 8 in Each Group). *** P < . 001 vs Control group;## P < .01, ### P < .001 vs Ang II Group.
Techniques Used: Staining, Control
Figure Legend Snippet: API Suppresses Renal Fibrosis and Modulates the Expression of Fibrosis-Related Genes in Ang II-Infused Mice. (A) Paraffin-Embedded Kidney Tissues Were Stained With Masson Trichrome (200×). (B) Quantitative Analysis of the Extent of Renal Fibrosis by Calculating the Percentage of Masson Collagen Area. RT-qPCR was Performed to Determine the mRNA Expression of Fibrosis-Related Genes: (C) Collagen I (COL1A1), (D) Collagen IV (COL4A1), (E) Fibronectin, (F) TGF-β1, and (G) α-SMA. Data Are Presented as Mean ± SD (n = 8 in Each Group). *** P < .001 vs Control Group; ### P < .001 vs Ang II Group. TGF-β1, Transforming Growth Factor-β1; α-SMA, α-smooth Muscle Actin.
Techniques Used: Expressing, Staining, Quantitative RT-PCR, Control
Figure Legend Snippet: API Attenuates Ang II-Induced Podocyte Injury and Modulates PI3K/Akt Pathway. (A) Cell Viability was Measured Using an MTT Assay. (B) MPC5 Cell Viability was Measured Using an MTT Assay. (C) Representative Gel Blots of PI3K/Akt Pathway Proteins by Western Blotting. (D, E) Quantification of Protein Bands of p-PI3K (Normalized to Total PI3K Protein) and p-Akt (Normalized to Total Akt Protein). Data Are Presented as Mean ± SD (n = 6 in Each Group). *** P < .001 vs Control Group; # P < .05 vs Ang II Group; ### P < .001 vs Ang II Group.
Techniques Used: MTT Assay, Western Blot, Control
Figure Legend Snippet: API Attenuates Ang II-Induced Apoptosis. (A) Apoptosis was Evaluated by Annexin V-FITC Double Staining, and Measured by Flow Cytometry. (B) Quantification of the Apoptotic Rate, which was Calculated by the Sum of the Lower Right Quadrant and the Upper Right Quadrant. Data Are Presented as Mean ± SD (n = 6 in Each Group). *** P < .001 vs Control Group; ### P < .001 vs Ang II Group; $$$ P < .001 vs Ang II + API Group.
Techniques Used: Double Staining, Flow Cytometry, Control
Figure Legend Snippet: API Reduces Ang II-Induced Intracellular ROS Generation and Oxidative Stress Through Inhibiting PI3K/Akt Pathway. (A) Intracellular ROS in Podocytes was Evaluated With DHE Staining and Photographed Under the Fluorescence Microscope (200×). (B) Quantification of the Percentage of DHE + Cells Relative to DAPI + Cells. The Oxidative Stress Indicators Were Measured in Cell Lysate: (C) MDA, (D) SOD and (E) GSH-Px. Data Are Shown as Mean ± SD (n = 6 per Group). *** P < .001 vs Control Group; ### P < .001 vs Ang II Group; $$$ P < .001 vs Ang II + API Group. ROS, Reactive Oxygen Species; DHE, Dihydroethidium; MDA, Malondialdehyde; SOD, Superoxide Dismutase; GSH-Px, Glutathione Peroxidase.
Techniques Used: Staining, Fluorescence, Microscopy, Control
Figure Legend Snippet: API Reduces Ang II-Induced Ferroptosis Through Inhibiting PI3K/Akt Pathway. (A) Mitochondrial Ferrous Iron was Evaluated With Mito FerroGreen Staining and Photographed Under the Fluorescence Microscope (200×). (B) Quantification of the Percentage of FerroGreen + Cells Relative to DAPI + Cells. Data Are Presented as Mean ± SD (n = 6 in Each Group). *** P < .001 vs Control Group; ### P < .001 vs Ang II Group; $$$ P < 0.001 vs Ang II + API Group.
Techniques Used: Staining, Fluorescence, Microscopy, Control
Figure Legend Snippet: API Modulates Ferroptosis-Rerated mRNA and Protein Expression by Activation of PI3K/Akt Pathway. RT-qPCR was Performed to Determine the mRNA Expression of Ferroptosis-Related Genes: (A) GPX4, (B) SLC7A11, and (C) ACSL4. (D) Representative Bands of Ferroptosis-Rerated Protein by Western Blot. Quantification of Proteins of (E) GPX4, (F) SLC7A11, and (G) ACSL4 (Normalized to GADPH Protein). Data Are Presented as Mean ± SD (n = 6 in Each Group). *** P < .001 vs Control Group; ### P < .001 vs Ang II Group; $$$ P < .001 vs Ang II + API Group.
Techniques Used: Expressing, Activation Assay, Quantitative RT-PCR, Western Blot, Control
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