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MedChemExpress corylifol a

A-D The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3, and SOCS3 in chorionic villi cultured with IL-6 and different concentrations of <t>Corylifol</t> <t>A</t> for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( A ) the correlation of the Corylifol A concentration added to chorionic villi cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( B ) the correlation of IDO1 expression with of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression ( C ) and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( D ) in chorionic villi cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. B The correlation coefficients (r) between the Corylifol A concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.96, − 0.88, − 0.95, − 0.9246, and 0.888, respectively; the P values for the correlation of IL-6 expression and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression were 0.01256, 0.0302, 0.014, 0.017 and 0.0408, respectively. C The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, STAT3 and SOCS3 were 0.972, 0.8361, 0.8735, 0.9865 and − 0.8165, respectively; the P value for correlation of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 was 0.0116, 0.026, 0.023, 0.007 and 0.028, respectively. D The correlation of the protein expression levels of SOCS3 and SHP-1/2 was − 0.9259/− 0.9983, respectively; the P value for correlation of the protein expression levels of SOCS3 and SHP-1/2 was 0.01755/0.0016, respectively. The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. E - H The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 in decidua cultured with IL-6 and different concentrations of Corylifol A (2–100 ng/ml) for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( E ), the correlation of Corylifol A concentration added to decidua cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( F ), the correlation of IDO1 expression with the expression of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( G ), and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( H ) in decidua cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. F The correlation coefficients (r) between Corylifol concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.83, − 0.92, − 0.9504, − 0.9248, − 0.87, and 0.732, respectively; the P values for the correlations of the levels of IL-6 and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.04, 0.03, 0.014, 0.017, 0.03 and 0.042, respectively. G The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.9724, 0.8361, 0.8735, 0.9672 and − 0.9724, respectively; the P values for correlations of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.010, 0.02, 0.023, 0.004 and 0.0106, respectively. H The correlation of the protein expression level of SOCS3 and SHP-1/2 was − 0.8368/− 0.8614, respectively; the P value for the correlation of the protein expression levels SOCS3 and SHP-1/2 was 0.026/0.024, respectively The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase

Corylifol A, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Molecular mechanisms involved in the IL-6-mediated upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression in the chorionic villi and decidua of women in early pregnancy"

Article Title: Molecular mechanisms involved in the IL-6-mediated upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression in the chorionic villi and decidua of women in early pregnancy

Journal: BMC Pregnancy and Childbirth

doi: 10.1186/s12884-022-05307-5

A-D The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3, and SOCS3 in chorionic villi cultured with IL-6 and different concentrations of Corylifol A for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( A ) the correlation of the Corylifol A concentration added to chorionic villi cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( B ) the correlation of IDO1 expression with of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression ( C ) and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( D ) in chorionic villi cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. B The correlation coefficients (r) between the Corylifol A concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.96, − 0.88, − 0.95, − 0.9246, and 0.888, respectively; the P values for the correlation of IL-6 expression and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression were 0.01256, 0.0302, 0.014, 0.017 and 0.0408, respectively. C The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, STAT3 and SOCS3 were 0.972, 0.8361, 0.8735, 0.9865 and − 0.8165, respectively; the P value for correlation of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 was 0.0116, 0.026, 0.023, 0.007 and 0.028, respectively. D The correlation of the protein expression levels of SOCS3 and SHP-1/2 was − 0.9259/− 0.9983, respectively; the P value for correlation of the protein expression levels of SOCS3 and SHP-1/2 was 0.01755/0.0016, respectively. The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. E - H The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 in decidua cultured with IL-6 and different concentrations of Corylifol A (2–100 ng/ml) for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( E ), the correlation of Corylifol A concentration added to decidua cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( F ), the correlation of IDO1 expression with the expression of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( G ), and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( H ) in decidua cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. F The correlation coefficients (r) between Corylifol concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.83, − 0.92, − 0.9504, − 0.9248, − 0.87, and 0.732, respectively; the P values for the correlations of the levels of IL-6 and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.04, 0.03, 0.014, 0.017, 0.03 and 0.042, respectively. G The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.9724, 0.8361, 0.8735, 0.9672 and − 0.9724, respectively; the P values for correlations of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.010, 0.02, 0.023, 0.004 and 0.0106, respectively. H The correlation of the protein expression level of SOCS3 and SHP-1/2 was − 0.8368/− 0.8614, respectively; the P value for the correlation of the protein expression levels SOCS3 and SHP-1/2 was 0.026/0.024, respectively The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase

Figure Legend Snippet: A-D The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3, and SOCS3 in chorionic villi cultured with IL-6 and different concentrations of Corylifol A for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( A ) the correlation of the Corylifol A concentration added to chorionic villi cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( B ) the correlation of IDO1 expression with of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression ( C ) and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( D ) in chorionic villi cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. B The correlation coefficients (r) between the Corylifol A concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.96, − 0.88, − 0.95, − 0.9246, and 0.888, respectively; the P values for the correlation of IL-6 expression and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 expression were 0.01256, 0.0302, 0.014, 0.017 and 0.0408, respectively. C The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, STAT3 and SOCS3 were 0.972, 0.8361, 0.8735, 0.9865 and − 0.8165, respectively; the P value for correlation of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 was 0.0116, 0.026, 0.023, 0.007 and 0.028, respectively. D The correlation of the protein expression levels of SOCS3 and SHP-1/2 was − 0.9259/− 0.9983, respectively; the P value for correlation of the protein expression levels of SOCS3 and SHP-1/2 was 0.01755/0.0016, respectively. The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. E - H The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 in decidua cultured with IL-6 and different concentrations of Corylifol A (2–100 ng/ml) for 24 h and the correlation of these expression levels, as measured by Western blotting analysis. The expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( E ), the correlation of Corylifol A concentration added to decidua cultures with the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( F ), the correlation of IDO1 expression with the expression of SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 ( G ), and the correlation of SOCS3 expression with the expression of SHP-1 and SHP-2 ( H ) in decidua cultured with 2 ng/ml IL-6 and different concentrations of Corylifol (0, 1, or 10 μg/ml) for 24 h were evaluated and analysed. The data are presented as the mean ± SE of three similar experiments. F The correlation coefficients (r) between Corylifol concentration added to chorionic villi cultures and the expression of IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were − 0.83, − 0.92, − 0.9504, − 0.9248, − 0.87, and 0.732, respectively; the P values for the correlations of the levels of IL-6 and IDO1, SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.04, 0.03, 0.014, 0.017, 0.03 and 0.042, respectively. G The correlation coefficients (r) of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.9724, 0.8361, 0.8735, 0.9672 and − 0.9724, respectively; the P values for correlations of the protein expression levels of IDO1 and SHP-1, SHP-2, STAT3, pSTAT3 and SOCS3 were 0.010, 0.02, 0.023, 0.004 and 0.0106, respectively. H The correlation of the protein expression level of SOCS3 and SHP-1/2 was − 0.8368/− 0.8614, respectively; the P value for the correlation of the protein expression levels SOCS3 and SHP-1/2 was 0.026/0.024, respectively The greyscale ratios of IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 and the expression levels of IDO1, SOCS3, SHP-1/2, STAT3 and pSTAT3 were assessed based on the ratios of the greyscale values of the IDO1, SOCS3, SHP-1, SHP-2, STAT3 and pSTAT3 bands to that of the GAPDH band. IDO1, indoleamine 2,3-dioxygenase; SOCS3, suppressors of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; pSTAT3, phosphorylated STAT3; SHP-1/2, protein tyrosine phosphatase-1/2; IL-6, interleukin-6; GAPDH, glyceraldehyde 3-phosphate dehydrogenase

Techniques Used: Expressing, Cell Culture, Western Blot, Concentration Assay

96 Well Plates:

Article Title: Corylifol A alleviates rheumatoid arthritis by targeting HSP90α and suppressing Wnt/β-catenin signaling.
Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

CCK-8 Assay:

Saline:

Article Title: Molecular mechanisms involved in the IL-6-mediated upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression in the chorionic villi and decidua of women in early pregnancy.
Article Snippet: Tissue explants were then placed into a CO2 incubator (37 °C, 5% CO2, approximately 0.1 g explants) (Thermo Fisher Scientific, USA) and cultured with 2 mL culture medium. .. IL-6 (PEPROTECH, USA) was diluted in 0.1% BSA (Sigma–Aldrich, USA) and PBS (Sigma–Aldrich); Corylifol A (MedChemExpress, USA) was diluted with 10% DMSO (Sigma–Aldrich), 40% PEG300 (MedChemExpress), 5% Tween-80 (Sigma– Aldrich) and 45% saline (Sigma–Aldrich). ..

Article Title: Molecular mechanisms involved in the IL-6-mediated upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression in the chorionic villi and decidua of women in early pregnancy
Article Snippet: Tissue explants were then placed into a CO 2 incubator (37 °C, 5% CO 2 , approximately 0.1 g explants) (Thermo Fisher Scientific, USA) and cultured with 2 mL culture medium. .. IL-6 (PEPROTECH, USA) was diluted in 0.1% BSA (Sigma–Aldrich, USA) and PBS (Sigma–Aldrich); Corylifol A (MedChemExpress, USA) was diluted with 10% DMSO (Sigma–Aldrich), 40% PEG300 (MedChemExpress), 5% Tween-80 (Sigma–Aldrich) and 45% saline (Sigma–Aldrich). ..

Control:

Article Title: 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L.
Article Snippet: Psoralea corylifolia L. (P. corylifolia) has attracted increasing attention because of its potential hepatotoxicity.. In this study, we used network analysis (toxic component and hepatotoxic target prediction, protein–protein interaction, GO enrichment analysis, KEGG pathway analysis, and molecular docking) to predict the components and mechanism of P. corylifolia-induced hepatotoxicity and then selected 4-hydroxylonchocarpin and corylifol A for experimental verification.. HepG2 cells were treated with low, medium, and high concentrations of 4-hydroxylonchocarpin or corylifol A.

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