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tenuigenin  (MedChemExpress)


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    Structured Review

    MedChemExpress tenuigenin
    The target screen of <t>Tenuigenin</t> in adult pneumonia. ( A ) The image showed the 2D structure of Tenuigenin. ( B ) The Venn diagram showed that 78 targets were screened from the intersection of the 100 Tenuigenin targets from the SwissTargetPrediction database and the 7246 adult pneumonia targets from the GeneCards database. ( C ) The PPI network of the 78 common targets was analyzed by the String website and optimized by the Cytoscape software (The darker the color, the higher the Degree value). ( D ) The bubble diagram showed the GO enrichment analysis of the 78 common targets conducted by the SangerBox. ( E ) The bubble diagram showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox. ( F ) The loop graph showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox
    Tenuigenin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n0802/Tenuigenin/pmc12481841-39-4-13
    Average 94 stars, based on 2 article reviews
    tenuigenin - by Bioz Stars, 2026-10
    94/100 stars

    Images

    1) Product Images from "Investigating the effect of tenuigenin on LPS-induced HPMEC dysfunction by inhibiting SRC activation based on network pharmacology and molecular docking"

    Article Title: Investigating the effect of tenuigenin on LPS-induced HPMEC dysfunction by inhibiting SRC activation based on network pharmacology and molecular docking

    Journal: Hereditas

    doi: 10.1186/s41065-025-00574-6

    The target screen of Tenuigenin in adult pneumonia. ( A ) The image showed the 2D structure of Tenuigenin. ( B ) The Venn diagram showed that 78 targets were screened from the intersection of the 100 Tenuigenin targets from the SwissTargetPrediction database and the 7246 adult pneumonia targets from the GeneCards database. ( C ) The PPI network of the 78 common targets was analyzed by the String website and optimized by the Cytoscape software (The darker the color, the higher the Degree value). ( D ) The bubble diagram showed the GO enrichment analysis of the 78 common targets conducted by the SangerBox. ( E ) The bubble diagram showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox. ( F ) The loop graph showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox
    Figure Legend Snippet: The target screen of Tenuigenin in adult pneumonia. ( A ) The image showed the 2D structure of Tenuigenin. ( B ) The Venn diagram showed that 78 targets were screened from the intersection of the 100 Tenuigenin targets from the SwissTargetPrediction database and the 7246 adult pneumonia targets from the GeneCards database. ( C ) The PPI network of the 78 common targets was analyzed by the String website and optimized by the Cytoscape software (The darker the color, the higher the Degree value). ( D ) The bubble diagram showed the GO enrichment analysis of the 78 common targets conducted by the SangerBox. ( E ) The bubble diagram showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox. ( F ) The loop graph showed the KEGG enrichment analysis of the 78 common targets conducted by the SangerBox

    Techniques Used: Software

    Tenuigenin promotes the viability of LPS-induced HPMECs. ( A ) CCK8 was used to detect the viability of HPMECs treated with Tenuigenin at 0, 0.5, 1, 2, 4, 8, and 16 µg/mL. ( B ) CCK8 was used to detect the viability of HPMECs treated with Tenuigenin (0, 0.5, 1, 2, and 4 µg/mL) and LPS (1 µg/mL). All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001
    Figure Legend Snippet: Tenuigenin promotes the viability of LPS-induced HPMECs. ( A ) CCK8 was used to detect the viability of HPMECs treated with Tenuigenin at 0, 0.5, 1, 2, 4, 8, and 16 µg/mL. ( B ) CCK8 was used to detect the viability of HPMECs treated with Tenuigenin (0, 0.5, 1, 2, and 4 µg/mL) and LPS (1 µg/mL). All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001

    Techniques Used:

    Tenuigenin mitigates LPS-induced HPMEC dysfunction. The HPMECs were co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). ( A ) EdU staining was applied to measure the EdU-positive cells. ( B ) The migrated cells were determined by transwell assay. ( C ) The angiogenesis was examined by tube formation assay. ( D ) Flow cytometry was employed to detect apoptosis. ( E ) The calcium ions levels were evaluated by the Fluo-4 Calcium Assay Kit. ( F ) The ROS levels were estimated by flow cytometry. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001
    Figure Legend Snippet: Tenuigenin mitigates LPS-induced HPMEC dysfunction. The HPMECs were co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). ( A ) EdU staining was applied to measure the EdU-positive cells. ( B ) The migrated cells were determined by transwell assay. ( C ) The angiogenesis was examined by tube formation assay. ( D ) Flow cytometry was employed to detect apoptosis. ( E ) The calcium ions levels were evaluated by the Fluo-4 Calcium Assay Kit. ( F ) The ROS levels were estimated by flow cytometry. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001

    Techniques Used: Staining, Transwell Assay, Tube Formation Assay, Flow Cytometry, Calcium Assay

    Tenuigenin impairs the cell permeability of LPS-induced HPMECs. The HPMECs were co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). ( A ) The TER was measured by the TER method. ( B ) The cell permeability was determined by transwell assay. ( C-E ) Western blot was applied to examine the protein expression of VE-cadherin and ZO-1. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001
    Figure Legend Snippet: Tenuigenin impairs the cell permeability of LPS-induced HPMECs. The HPMECs were co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). ( A ) The TER was measured by the TER method. ( B ) The cell permeability was determined by transwell assay. ( C-E ) Western blot was applied to examine the protein expression of VE-cadherin and ZO-1. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001

    Techniques Used: Permeability, Transwell Assay, Western Blot, Expressing

    SRC is the target of Tenuigenin in adult pneumonia. ( A ) The TOP 10 hub genes of Tenuigenin in adult pneumonia were screened according to the MNC, MCC, and Degree values of the CytoHubba. ( B ) The image showed the 3D structure of SRC. ( C ) The 3D image showed the optimal conformation of Tenuigenin and SRC (affinity: -9.6 kcal/mol) visualized by the PyMOL software. ( D ) The 3D combination image of Tenuigenin and SRC was visualized by the PyMOL software. ( E ) The 2D combination image of Tenuigenin and SRC was visualized by the Discovery Studio 4.5 software. ( F ) Western blot was applied to examine the protein expression of SRC and p-SRC in HPMECs co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). All experiments were repeated three times. *** P < 0.001
    Figure Legend Snippet: SRC is the target of Tenuigenin in adult pneumonia. ( A ) The TOP 10 hub genes of Tenuigenin in adult pneumonia were screened according to the MNC, MCC, and Degree values of the CytoHubba. ( B ) The image showed the 3D structure of SRC. ( C ) The 3D image showed the optimal conformation of Tenuigenin and SRC (affinity: -9.6 kcal/mol) visualized by the PyMOL software. ( D ) The 3D combination image of Tenuigenin and SRC was visualized by the PyMOL software. ( E ) The 2D combination image of Tenuigenin and SRC was visualized by the Discovery Studio 4.5 software. ( F ) Western blot was applied to examine the protein expression of SRC and p-SRC in HPMECs co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL). All experiments were repeated three times. *** P < 0.001

    Techniques Used: Software, Western Blot, Expressing

    Tenuigenin weakens LPS-induced HPMEC injury and dysfunction through the SRC pathway. The HPMECs were treated with LPS, Tenuigenin, and AZM475271. ( A ) Western blot was used to examine the protein expression of SRC and p-SRC. ( B ) EdU staining was applied to measure the EdU-positive cells. ( C ) The migrated cells were determined by transwell assay. ( D ) The angiogenesis was examined by tube formation assay. ( E ) Flow cytometry was employed to detect apoptosis. ( F ) The calcium ions levels were evaluated by the Fluo-4 Calcium Assay Kit. ( G ) The ROS levels were estimated by flow cytometry. ( H ) The TER was measured by the TER method. ( I ) The cell permeability was determined by transwell assay. ( J ) Western blot was employed to examine the protein expression of VE-cadherin and ZO-1. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001
    Figure Legend Snippet: Tenuigenin weakens LPS-induced HPMEC injury and dysfunction through the SRC pathway. The HPMECs were treated with LPS, Tenuigenin, and AZM475271. ( A ) Western blot was used to examine the protein expression of SRC and p-SRC. ( B ) EdU staining was applied to measure the EdU-positive cells. ( C ) The migrated cells were determined by transwell assay. ( D ) The angiogenesis was examined by tube formation assay. ( E ) Flow cytometry was employed to detect apoptosis. ( F ) The calcium ions levels were evaluated by the Fluo-4 Calcium Assay Kit. ( G ) The ROS levels were estimated by flow cytometry. ( H ) The TER was measured by the TER method. ( I ) The cell permeability was determined by transwell assay. ( J ) Western blot was employed to examine the protein expression of VE-cadherin and ZO-1. All experiments were repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001

    Techniques Used: Western Blot, Expressing, Staining, Transwell Assay, Tube Formation Assay, Flow Cytometry, Calcium Assay, Permeability

    Related Articles

    Sterility:

    Article Title: Tenuigenin promotes non-rapid eye movement sleep via the GABA A receptor and exerts somnogenic effect in a MPTP mouse model of Parkinson's disease.
    Article Snippet: Diazepam (purchased from Beijing Tiantan Hospital, China) at 6 mg⋅kg− 1 was diluted with sterile saline. .. Flumazenil (Flu; MedChemExpress, HY-B0009, USA) at 0.5 mg⋅kg− 1 was dissolved in sterile saline, which was injected 15 min before the injection of tenuigenin, and the dosages were depended on the previous studies [15]. .. MPTP (Beyotime Biotechnology, ST1020–100 mg, China) at 20 mg⋅kg− 1 was diluted with sterile saline to build subacute PD models [16].

    Saline:

    Article Title: Tenuigenin promotes non-rapid eye movement sleep via the GABA A receptor and exerts somnogenic effect in a MPTP mouse model of Parkinson's disease.
    Article Snippet: Diazepam (purchased from Beijing Tiantan Hospital, China) at 6 mg⋅kg− 1 was diluted with sterile saline. .. Flumazenil (Flu; MedChemExpress, HY-B0009, USA) at 0.5 mg⋅kg− 1 was dissolved in sterile saline, which was injected 15 min before the injection of tenuigenin, and the dosages were depended on the previous studies [15]. .. MPTP (Beyotime Biotechnology, ST1020–100 mg, China) at 20 mg⋅kg− 1 was diluted with sterile saline to build subacute PD models [16].

    Injection:

    Article Title: Tenuigenin promotes non-rapid eye movement sleep via the GABA A receptor and exerts somnogenic effect in a MPTP mouse model of Parkinson's disease.
    Article Snippet: Diazepam (purchased from Beijing Tiantan Hospital, China) at 6 mg⋅kg− 1 was diluted with sterile saline. .. Flumazenil (Flu; MedChemExpress, HY-B0009, USA) at 0.5 mg⋅kg− 1 was dissolved in sterile saline, which was injected 15 min before the injection of tenuigenin, and the dosages were depended on the previous studies [15]. .. MPTP (Beyotime Biotechnology, ST1020–100 mg, China) at 20 mg⋅kg− 1 was diluted with sterile saline to build subacute PD models [16].



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