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isoquercitrin  (MedChemExpress)


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    Structured Review

    MedChemExpress isoquercitrin
    Isoquercitrin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n0768/Quercetin+3-O-%CE%B2-D-glucofuranoside/pm38065271-51-0-14
    Average 91 stars, based on 2 article reviews
    isoquercitrin - by Bioz Stars, 2026-10
    91/100 stars

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    Related Articles

    Tandem Mass Spectroscopy:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Methylation:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Conjugation Assay:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Concentration Assay:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Activation Assay:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Modification:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Quantitative RT-PCR:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Enzyme-linked Immunosorbent Assay:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

    Expressing:

    Article Title: Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
    Article Snippet: In addition, quercetin, myricetin, hyperoside, quercetin-3′-glucoside were supplied by Suzhong Pharmaceutical Group Co., Ltd. Hibifolin, rutin, isoquercitrin, isorhamnetin, and DOPAC were purchased respectively from Selleck and MCE, Shanghai, China.

    Article Title: Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
    Article Snippet: An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA).. Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial.. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.



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    MedChemExpress isoquercitrin
    Isoquercitrin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n0768/Quercetin+3-O-%CE%B2-D-glucofuranoside/pm38065271-51-0-14
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    MedChemExpress iqc
    <t>IQC</t> administration suppressed inflammatory response and oxidative stress in mice treated with cisplatin. (A–C) qRT-PCR was performed to analyze the mRNA levels of renal IL-6 (A) , TNF-α (B) , IL-1β (C) and COX-2 (D) . (E,F) The protein levels of circulating IL-6 (E) and TNF-α (F) were analyzed by ELISA. (G) Representative immune blots of P-p65 and p65. GAPDH was used as the internal reference. (H–J) Densitometry analysis of P-p65 and p65. (K) The level of MDA in kidneys of experimental animals. (L) The expression of total glutathione in kidneys of mice. (M) Representative immune blots of p-ERK and ERK. GAPDH was used as the internal reference. (N,O) Densitometry analysis of p-ERK/GAPDH and p-ERK/t-ERK. (P,Q) The levels of serum creatinine (Scr) (P) and blood urea nitrogen (BUN) (Q) when pretreated with IQC <t>or</t> <t>U0126</t> following cisplatin administration. All the quantitative results were expressed as means ± S.D (n = 6 mice of each group). P-p65, phosphorylated p65; p-ERK, phosphorylated extracellular signal-regulated kinase; MDA, Malondialdehyde. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
    Iqc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hy-n0768/Isoquercitrin/pmc07793722-44-0-8
    Average 91 stars, based on 1 article reviews
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    Image Search Results


    IQC administration suppressed inflammatory response and oxidative stress in mice treated with cisplatin. (A–C) qRT-PCR was performed to analyze the mRNA levels of renal IL-6 (A) , TNF-α (B) , IL-1β (C) and COX-2 (D) . (E,F) The protein levels of circulating IL-6 (E) and TNF-α (F) were analyzed by ELISA. (G) Representative immune blots of P-p65 and p65. GAPDH was used as the internal reference. (H–J) Densitometry analysis of P-p65 and p65. (K) The level of MDA in kidneys of experimental animals. (L) The expression of total glutathione in kidneys of mice. (M) Representative immune blots of p-ERK and ERK. GAPDH was used as the internal reference. (N,O) Densitometry analysis of p-ERK/GAPDH and p-ERK/t-ERK. (P,Q) The levels of serum creatinine (Scr) (P) and blood urea nitrogen (BUN) (Q) when pretreated with IQC or U0126 following cisplatin administration. All the quantitative results were expressed as means ± S.D (n = 6 mice of each group). P-p65, phosphorylated p65; p-ERK, phosphorylated extracellular signal-regulated kinase; MDA, Malondialdehyde. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Journal: Frontiers in Pharmacology

    Article Title: Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress

    doi: 10.3389/fphar.2020.599416

    Figure Lengend Snippet: IQC administration suppressed inflammatory response and oxidative stress in mice treated with cisplatin. (A–C) qRT-PCR was performed to analyze the mRNA levels of renal IL-6 (A) , TNF-α (B) , IL-1β (C) and COX-2 (D) . (E,F) The protein levels of circulating IL-6 (E) and TNF-α (F) were analyzed by ELISA. (G) Representative immune blots of P-p65 and p65. GAPDH was used as the internal reference. (H–J) Densitometry analysis of P-p65 and p65. (K) The level of MDA in kidneys of experimental animals. (L) The expression of total glutathione in kidneys of mice. (M) Representative immune blots of p-ERK and ERK. GAPDH was used as the internal reference. (N,O) Densitometry analysis of p-ERK/GAPDH and p-ERK/t-ERK. (P,Q) The levels of serum creatinine (Scr) (P) and blood urea nitrogen (BUN) (Q) when pretreated with IQC or U0126 following cisplatin administration. All the quantitative results were expressed as means ± S.D (n = 6 mice of each group). P-p65, phosphorylated p65; p-ERK, phosphorylated extracellular signal-regulated kinase; MDA, Malondialdehyde. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Article Snippet: IQC (HY-N0768) and U0126 (HY-12031) were purchased from MedChemExpress (MJ, NJ, United States).

    Techniques: Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay, Expressing