Review



5 7 dichlorokynurenic acid 5 7 dck  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 94

    Structured Review

    Tocris 5 7 dichlorokynurenic acid 5 7 dck
    5 7 Dichlorokynurenic Acid 5 7 Dck, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/5%2C7-Dichlorokynurenic+acid/10__1097_slash_wnr__0b013e32833313b7-18-50-58
    Average 94 stars, based on 26 article reviews
    5 7 dichlorokynurenic acid 5 7 dck - by Bioz Stars, 2026-09
    94/100 stars

    Images

    Related Articles

    other:

    Article Title: Neuroprotection against supra-lethal 'stroke in a dish' insults by an anti-excitotoxic receptor antagonist cocktail.
    Article Snippet: The goal of this study was to identify cocktails of drugs able to protect cultured rodent cortical neurons against increasing durations of oxygen-glucose deprivation (OGD).. As expected, a cocktail composed of an NMDA and AMPA receptor antagonists and a voltage gated Ca2+ channel blocker (MK-801, CNQX and nifedipine, respectively) provided complete neuroprotection against mild OGD.. Increasingly longer durations of OGD necessitated increasing the doses of MK-801 and CNQX, until these cocktails ultimately failed to provide neuroprotection against supra-lethal OGD, even at maximal drug concentrations.

    Article Title: Heteroaromatic NMDA receptor modulators and uses thereof
    Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM 5,7-dichlorokynurenic acid (both purchased from Tocris Bioscience (Bristol, England) and maintained as 10 mM stock solutions in 100% DMSO).

    Article Title: Hydrogen sulfide and polysulfides induce GABA/glutamate/D-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity.
    Article Snippet: 5,7-Dichlorokynurenic acid (DCKA) was obtained from Tocris Bioscience (Avonmouth, UK). d-Serine and the other chemicals were from Wako Pure Chemical Industries, Ltd. (Osaka, Japan).

    Article Title: D-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility
    Article Snippet: N-Methyl D-aspartate (NMDA), CGP78608, 5,7-Dichlorokynurenic acid (5,7DCKA), CNQX and D(−)-2-Amino-5-phosphonopentanoic acid (D-AP5) were from Tocris Biosciences.

    Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof
    Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM 5,7-dichlorokynurenic acid (both purchased from Tocris Bioscience (Bristol, England) and maintained as 10 mM stock solutions in 100% DMSO).

    Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof
    Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM 5,7-dichlorokynurenic acid (both purchased from Tocris Bioscience (Bristol, England) and maintained as 10 mM stock solutions in 100% DMSO).

    Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof
    Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM 5,7-dichlorokynurenic acid (both purchased from Tocris Bioscience (Bristol, England) and maintained as 10 mM stock solutions in 100% DMSO).



    Similar Products

    99
    ATCC crl 1446 rrid cvcl 0286
    Crl 1446 Rrid Cvcl 0286, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/H9c2(2-1)/pmc13056360-1-11-19
    Average 99 stars, based on 1 article reviews
    crl 1446 rrid cvcl 0286 - by Bioz Stars, 2026-09
    99/100 stars
      Buy from Supplier

    93
    Tocris 5 7 dichlorokynurenic acid
    5 7 Dichlorokynurenic Acid, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/5%2C7-Dichlorokynurenic+acid/pmc12971058-249-40-54
    Average 93 stars, based on 1 article reviews
    5 7 dichlorokynurenic acid - by Bioz Stars, 2026-09
    93/100 stars
      Buy from Supplier

    86
    Scientific Industries Inc si 0286
    Si 0286, supplied by Scientific Industries Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/mixer+vortex+%EA%B8%B0%EA%B8%B0%EB%8A%94+%EC%82%AC%EC%9A%A9%EB%90%9C+%EC%8B%A4%ED%97%98%EC%97%90/pmc12483594-232-6-3
    Average 86 stars, based on 1 article reviews
    si 0286 - by Bioz Stars, 2026-09
    86/100 stars
      Buy from Supplier

    90
    Procell Inc h9c2 cells (rattus norvegicus, embryonic heart, cvcl 0286, scsp-5211)
    QXJYG reduces inflammatory cytokine content in hypoxia-induced <t>H9C2</t> cells via the MK2/TTP pathway suppression. (A and B) The optimal concentrations of QXJYG and ISMN intervention in H9C2 cells was evaluated by CCK-8 assay, respectively. (C–E) The mRNA levels of pro-inflammatory factors IL-6, IL-1β and TNF-α were measured via RT-qPCR analysis ( n = 3). (F–H) The protein levels of p-MK2, MK2, TTP and Vinculin were measured via western blot analysis ( n = 3); Vinculin was used as the internal control. * P < 0.05; *** P < 0.001,vs. Control group. # P < 0.05; ## P < 0.01; ### P < 0.001,vs. Model group. IL: interleukin; TNF: tumor necrosis factor; MK2: mitogen-activated protein kinase-activated protein kinase 2; TTP: tristetraprolin.
    H9c2 Cells (Rattus Norvegicus, Embryonic Heart, Cvcl 0286, Scsp 5211), supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/h9c2+cells/pmc11849043-67-0-12
    Average 90 stars, based on 1 article reviews
    h9c2 cells (rattus norvegicus, embryonic heart, cvcl 0286, scsp-5211) - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    Beijing Solarbio Science mouse e2 (estradiol) elisa kit cat#sekm-0286
    QXJYG reduces inflammatory cytokine content in hypoxia-induced <t>H9C2</t> cells via the MK2/TTP pathway suppression. (A and B) The optimal concentrations of QXJYG and ISMN intervention in H9C2 cells was evaluated by CCK-8 assay, respectively. (C–E) The mRNA levels of pro-inflammatory factors IL-6, IL-1β and TNF-α were measured via RT-qPCR analysis ( n = 3). (F–H) The protein levels of p-MK2, MK2, TTP and Vinculin were measured via western blot analysis ( n = 3); Vinculin was used as the internal control. * P < 0.05; *** P < 0.001,vs. Control group. # P < 0.05; ## P < 0.01; ### P < 0.001,vs. Model group. IL: interleukin; TNF: tumor necrosis factor; MK2: mitogen-activated protein kinase-activated protein kinase 2; TTP: tristetraprolin.
    Mouse E2 (Estradiol) Elisa Kit Cat#Sekm 0286, supplied by Beijing Solarbio Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/mouse+e2++estradiol++elisa+kit+cat+sekm+0286/pm39956405-90-29-35
    Average 90 stars, based on 1 article reviews
    mouse e2 (estradiol) elisa kit cat#sekm-0286 - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    Fabrication Enterprises Inc digital dynamometer smedley digital hand dynamometer, model: 12–0286
    QXJYG reduces inflammatory cytokine content in hypoxia-induced <t>H9C2</t> cells via the MK2/TTP pathway suppression. (A and B) The optimal concentrations of QXJYG and ISMN intervention in H9C2 cells was evaluated by CCK-8 assay, respectively. (C–E) The mRNA levels of pro-inflammatory factors IL-6, IL-1β and TNF-α were measured via RT-qPCR analysis ( n = 3). (F–H) The protein levels of p-MK2, MK2, TTP and Vinculin were measured via western blot analysis ( n = 3); Vinculin was used as the internal control. * P < 0.05; *** P < 0.001,vs. Control group. # P < 0.05; ## P < 0.01; ### P < 0.001,vs. Model group. IL: interleukin; TNF: tumor necrosis factor; MK2: mitogen-activated protein kinase-activated protein kinase 2; TTP: tristetraprolin.
    Digital Dynamometer Smedley Digital Hand Dynamometer, Model: 12–0286, supplied by Fabrication Enterprises Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0286/digital+dynamometer+smedley+digital+hand+dynamometer++model++12+0286/pm39616892-66-6-14
    Average 90 stars, based on 1 article reviews
    digital dynamometer smedley digital hand dynamometer, model: 12–0286 - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    Image Search Results


    QXJYG reduces inflammatory cytokine content in hypoxia-induced H9C2 cells via the MK2/TTP pathway suppression. (A and B) The optimal concentrations of QXJYG and ISMN intervention in H9C2 cells was evaluated by CCK-8 assay, respectively. (C–E) The mRNA levels of pro-inflammatory factors IL-6, IL-1β and TNF-α were measured via RT-qPCR analysis ( n = 3). (F–H) The protein levels of p-MK2, MK2, TTP and Vinculin were measured via western blot analysis ( n = 3); Vinculin was used as the internal control. * P < 0.05; *** P < 0.001,vs. Control group. # P < 0.05; ## P < 0.01; ### P < 0.001,vs. Model group. IL: interleukin; TNF: tumor necrosis factor; MK2: mitogen-activated protein kinase-activated protein kinase 2; TTP: tristetraprolin.

    Journal: Pharmaceutical Biology

    Article Title: Qing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway

    doi: 10.1080/13880209.2025.2467377

    Figure Lengend Snippet: QXJYG reduces inflammatory cytokine content in hypoxia-induced H9C2 cells via the MK2/TTP pathway suppression. (A and B) The optimal concentrations of QXJYG and ISMN intervention in H9C2 cells was evaluated by CCK-8 assay, respectively. (C–E) The mRNA levels of pro-inflammatory factors IL-6, IL-1β and TNF-α were measured via RT-qPCR analysis ( n = 3). (F–H) The protein levels of p-MK2, MK2, TTP and Vinculin were measured via western blot analysis ( n = 3); Vinculin was used as the internal control. * P < 0.05; *** P < 0.001,vs. Control group. # P < 0.05; ## P < 0.01; ### P < 0.001,vs. Model group. IL: interleukin; TNF: tumor necrosis factor; MK2: mitogen-activated protein kinase-activated protein kinase 2; TTP: tristetraprolin.

    Article Snippet: H9C2 cells (Rattus norvegicus, embryonic heart, CVCL 0286, SCSP-5211), purchased from Wuhan Procell Life Science and Technology Co., Ltd., were cultured in DMEM supplemented with 10% FBS and 1% Penicillin-Streptomycin (100×) at 37 °C, in a 5% CO 2 atmosphere with saturated humidity until reaching 80–90% confluence for passaging and seeding.

    Techniques: CCK-8 Assay, Quantitative RT-PCR, Western Blot, Control