5 7 dichlorokynurenic acid 5 7 dck (Tocris)
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5 7 Dichlorokynurenic Acid 5 7 Dck, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/0286/5%2C7-Dichlorokynurenic+acid/10__1097_slash_wnr__0b013e32833313b7-18-50-58
Average 94 stars, based on 26 article reviews
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other:Article Title: Neuroprotection against supra-lethal 'stroke in a dish' insults by an anti-excitotoxic receptor antagonist cocktail. Article Snippet: The goal of this study was to identify cocktails of drugs able to protect cultured rodent cortical neurons against increasing durations of oxygen-glucose deprivation (OGD).. As expected, a cocktail composed of an NMDA and AMPA receptor antagonists and a voltage gated Ca2+ channel blocker (MK-801, CNQX and nifedipine, respectively) provided complete neuroprotection against mild OGD.. Increasingly longer durations of OGD necessitated increasing the doses of MK-801 and CNQX, until these cocktails ultimately failed to provide neuroprotection against supra-lethal OGD, even at maximal drug concentrations. Article Title: Heteroaromatic NMDA receptor modulators and uses thereof Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM Article Title: Hydrogen sulfide and polysulfides induce GABA/glutamate/D-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity. Article Snippet: 5,7-Dichlorokynurenic acid (DCKA) was obtained from Tocris Bioscience (Avonmouth, UK). d-Serine and the other chemicals were from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Article Title: D-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility Article Snippet: N-Methyl D-aspartate (NMDA), CGP78608, 5,7-Dichlorokynurenic acid (5,7DCKA), CNQX and D( Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM Article Title: Thienopyrimidinone NMDA receptor modulators and uses thereof Article Snippet: From stock solutions at 10 mM in 100% DMSO, compounds are spotted in the desired amounts using an ECHO liquid handler (Labcyte, Sunnyvale, Calif.) into wells of a 384-well plate and then diluted with 50 μl of HHnoCa containing 750 nM Ro 25-6981 and 120 μM |
