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l cyclohexylalanine  (Chem Impex International)


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    Structured Review

    Chem Impex International l cyclohexylalanine
    L Cyclohexylalanine, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/02560/b-Cyclohexyl-L-alanine/10__1080_slash_00397911__2016__1249289-127-11-20
    Average 95 stars, based on 3 article reviews
    l cyclohexylalanine - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Purification:

    Article Title: Compounds that interact with glucokinase regulatory protein for the treatment of diabetes
    Article Snippet: Following the procedure reported for Example 36, starting from N-(tert-butoxycarbonyl)-3-cyclohexylalanine (Chem-Impex, Wood Dale, Ill.) and coupling with 2-(4-bromophenyl)-1,1,1-trifluoro-2-propanol (Example 27, step 1) delivered 2-(4-(2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol (mixture of four isomers) after purification via column chromatography (40 g silica gel, 0.5 to 8% MeOH—CH2Cl2). (2R)-2-(4-((2R)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2R)-2-(4-((2S)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2S)-2-(4-((2R)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2S)-2-(4-((2S)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol.

    Column Chromatography:

    Article Title: Compounds that interact with glucokinase regulatory protein for the treatment of diabetes
    Article Snippet: Following the procedure reported for Example 36, starting from N-(tert-butoxycarbonyl)-3-cyclohexylalanine (Chem-Impex, Wood Dale, Ill.) and coupling with 2-(4-bromophenyl)-1,1,1-trifluoro-2-propanol (Example 27, step 1) delivered 2-(4-(2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol (mixture of four isomers) after purification via column chromatography (40 g silica gel, 0.5 to 8% MeOH—CH2Cl2). (2R)-2-(4-((2R)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2R)-2-(4-((2S)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2S)-2-(4-((2R)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; (2S)-2-(4-((2S)-2-(cyclohexylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol.



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