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Valiant Co Ltd β naphthoflavone
β Naphthoflavone, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/02195339%2E2/%CE%B2-naphthoflavone/pm39169259-327-23-24
Average 92 stars, based on 6 article reviews
β naphthoflavone - by Bioz Stars, 2026-09
92/100 stars

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Expressing:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. To induce low-frequency expression of EYFP in the mouse esophagus, 10–16-week-old transgenic mice were given a single intraperitoneal (i.p.) of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633) (AhcreERTRosa26flConfettiPik3cafl-H1047R-T2A-EYFP-NLS/wt) or 0.25 mg tamoxifen (other mouse strains), resulting in 2.9 ± 0.9% and 0.17 ± 0.04% (mean ± standard deviation (s.d.)) recombined epithelium by area, respectively, 10 days after induction. ..

Transgenic Assay:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. To induce low-frequency expression of EYFP in the mouse esophagus, 10–16-week-old transgenic mice were given a single intraperitoneal (i.p.) of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633) (AhcreERTRosa26flConfettiPik3cafl-H1047R-T2A-EYFP-NLS/wt) or 0.25 mg tamoxifen (other mouse strains), resulting in 2.9 ± 0.9% and 0.17 ± 0.04% (mean ± standard deviation (s.d.)) recombined epithelium by area, respectively, 10 days after induction. ..

Standard Deviation:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. To induce low-frequency expression of EYFP in the mouse esophagus, 10–16-week-old transgenic mice were given a single intraperitoneal (i.p.) of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633) (AhcreERTRosa26flConfettiPik3cafl-H1047R-T2A-EYFP-NLS/wt) or 0.25 mg tamoxifen (other mouse strains), resulting in 2.9 ± 0.9% and 0.17 ± 0.04% (mean ± standard deviation (s.d.)) recombined epithelium by area, respectively, 10 days after induction. ..

Injection:

Article Title: Somatic mutant selection is altered by prior NOTCH1 mutation in aging esophageal epithelium
Article Snippet: .. YFPCreNotch1 flox/flox mice aged between 10-16 weeks-old were injected intraperitoneally (i.p.) with β-Naphthoflavone (MP Biomedicals, catalog no.156738) at 80 mg.kg -1 and tamoxifen (Sigma Aldrich, catalog no. N3633) at 0.25mg and collected at up to 78 weeks old. ..

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Article Snippet: .. Three months after induction with one i.p. injection of 80 mg kg −1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. Analysis of in vivo proliferation by EdU labeling Three months after induction with one i.p. injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

Article Title: Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Article Snippet: .. Ahcre ERT - Trp53 flR245W-GFP/wt mice were induced to express the mutant p53 R245W allele and GFP reporter protein, by intraperitoneal injection of 80 mg kg −1 β-naphthoflavone (MP Biomedicals, cat. no. 156738) and 0.25 mg of tamoxifen (Sigma-Aldrich, cat. no. N3633) as previously described , . .. Once month later, mice were orally treated with the carcinogen diethylnitrosamine (Sigma, cat. no. N0756) in sweetened drinking water (40 mg 1,000 ml −1 ) for 24 h on 3 days a week (Monday, Wednesday and Friday), for 2 weeks to induce the formation of early lesions in the esophageal epithelium, followed by exposure to five doses of 2 Gy of ionizing radiation (2 Gy per week) using a whole-body cesium source irradiator.

Article Title: Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.
Article Snippet: .. Generation of p53* mutant transformed cells (p53*-TC) AhcreERT-Trp53flR245W-GFP/wt mice were induced to express the mutant p53R245W allele and GFP reporter protein, by intraperitoneal injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals, cat. no. 156738) and 0.25 mg of tamoxifen (Sigma-Aldrich, cat. no. N3633) as previously described36,38. .. Once month later, mice were orally treated with the carcinogen diethylnitrosamine (Sigma, cat. no. N0756) in sweetened drinking water (40 mg 1,000 ml−1) for 24 h on 3 days a week (Monday, Wednesday and Friday), for 2 weeks to induce the formation of early lesions in the esophageal epithelium, followed by exposure to five doses of 2 Gy of ionizing radiation (2 Gy per week) using a whole-body cesium source irradiator.

Saline:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Article Snippet: .. Three months after induction with one i.p. injection of 80 mg kg −1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. Analysis of in vivo proliferation by EdU labeling Three months after induction with one i.p. injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

In Vivo:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. Analysis of in vivo proliferation by EdU labeling Three months after induction with one i.p. injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

Labeling:

Article Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Article Snippet: .. Analysis of in vivo proliferation by EdU labeling Three months after induction with one i.p. injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals 156738) and 1 mg tamoxifen (Sigma-Aldrich N3633), 10 μg of EdU in phospate-buffered saline (PBS) was administered by i.p. injection 1 h before culling. ..

Mutagenesis:

Article Title: Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Article Snippet: .. Ahcre ERT - Trp53 flR245W-GFP/wt mice were induced to express the mutant p53 R245W allele and GFP reporter protein, by intraperitoneal injection of 80 mg kg −1 β-naphthoflavone (MP Biomedicals, cat. no. 156738) and 0.25 mg of tamoxifen (Sigma-Aldrich, cat. no. N3633) as previously described , . .. Once month later, mice were orally treated with the carcinogen diethylnitrosamine (Sigma, cat. no. N0756) in sweetened drinking water (40 mg 1,000 ml −1 ) for 24 h on 3 days a week (Monday, Wednesday and Friday), for 2 weeks to induce the formation of early lesions in the esophageal epithelium, followed by exposure to five doses of 2 Gy of ionizing radiation (2 Gy per week) using a whole-body cesium source irradiator.

Article Title: Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.
Article Snippet: .. Generation of p53* mutant transformed cells (p53*-TC) AhcreERT-Trp53flR245W-GFP/wt mice were induced to express the mutant p53R245W allele and GFP reporter protein, by intraperitoneal injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals, cat. no. 156738) and 0.25 mg of tamoxifen (Sigma-Aldrich, cat. no. N3633) as previously described36,38. .. Once month later, mice were orally treated with the carcinogen diethylnitrosamine (Sigma, cat. no. N0756) in sweetened drinking water (40 mg 1,000 ml−1) for 24 h on 3 days a week (Monday, Wednesday and Friday), for 2 weeks to induce the formation of early lesions in the esophageal epithelium, followed by exposure to five doses of 2 Gy of ionizing radiation (2 Gy per week) using a whole-body cesium source irradiator.

Transformation Assay:

Article Title: Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.
Article Snippet: .. Generation of p53* mutant transformed cells (p53*-TC) AhcreERT-Trp53flR245W-GFP/wt mice were induced to express the mutant p53R245W allele and GFP reporter protein, by intraperitoneal injection of 80 mg kg−1 β-naphthoflavone (MP Biomedicals, cat. no. 156738) and 0.25 mg of tamoxifen (Sigma-Aldrich, cat. no. N3633) as previously described36,38. .. Once month later, mice were orally treated with the carcinogen diethylnitrosamine (Sigma, cat. no. N0756) in sweetened drinking water (40 mg 1,000 ml−1) for 24 h on 3 days a week (Monday, Wednesday and Friday), for 2 weeks to induce the formation of early lesions in the esophageal epithelium, followed by exposure to five doses of 2 Gy of ionizing radiation (2 Gy per week) using a whole-body cesium source irradiator.



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