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Valiant Co Ltd nitrofurantoin
Plasma concentration vs time profiles of <t>nitrofurantoin</t> in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral and intravenous administration. The plasma concentration vs time profiles of nitrofurantoin in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral administration (2 mg/kg; A, B) and intravenous administration (1 mg/kg; C, D). Each point is expressed as means ± SD (po: n = 3) or means (iv; n = 2)
Nitrofurantoin, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 96/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/0215588125/Nitrofurantoin/pmc06968775-80-0-4
Average 96 stars, based on 9 article reviews
nitrofurantoin - by Bioz Stars, 2026-09
96/100 stars

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1) Product Images from "Assessment of contribution of BCRP to intestinal absorption of various drugs using portal‐systemic blood concentration difference model in mice"

Article Title: Assessment of contribution of BCRP to intestinal absorption of various drugs using portal‐systemic blood concentration difference model in mice

Journal: Pharmacology Research & Perspectives

doi: 10.1002/prp2.544

Plasma concentration vs time profiles of nitrofurantoin in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral and intravenous administration. The plasma concentration vs time profiles of nitrofurantoin in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral administration (2 mg/kg; A, B) and intravenous administration (1 mg/kg; C, D). Each point is expressed as means ± SD (po: n = 3) or means (iv; n = 2)
Figure Legend Snippet: Plasma concentration vs time profiles of nitrofurantoin in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral and intravenous administration. The plasma concentration vs time profiles of nitrofurantoin in WT, Bcrp(−/−), and Mdr1a/1b(−/−) mice after oral administration (2 mg/kg; A, B) and intravenous administration (1 mg/kg; C, D). Each point is expressed as means ± SD (po: n = 3) or means (iv; n = 2)

Techniques Used: Concentration Assay

Pharmacokinetic parameters of  nitrofurantoin  after oral and intravenous administration to wild‐type, Bcrp(−/−), and Mdr1a/1b(−/−) mice
Figure Legend Snippet: Pharmacokinetic parameters of nitrofurantoin after oral and intravenous administration to wild‐type, Bcrp(−/−), and Mdr1a/1b(−/−) mice

Techniques Used:

Data summary for k a and in vivo AQ values
Figure Legend Snippet: Data summary for k a and in vivo AQ values

Techniques Used: In Vivo

Data summary for F a F g and rate of contribution ( R ) values in vivo
Figure Legend Snippet: Data summary for F a F g and rate of contribution ( R ) values in vivo

Techniques Used:

Relationship between in vitro AQ and in vivo contribution ratio ( R ) for 4 model drugs. Open or closed circles represent the relationship between in vitro AQ P‐gp and in vivo R P‐gp or in vitro AQ BCRP and in vivo R bcrp , respectively. In vitro AQ values were cited from our previous report (Kawahara et al, manuscript in revision). Key: 1, ciprofloxacin; 2, nitrofurantoin; 3, topotecan; 4, sulfasalazine. F (˗): False negative, F (+): False positive, T (˗): True negative, T (+): True positive
Figure Legend Snippet: Relationship between in vitro AQ and in vivo contribution ratio ( R ) for 4 model drugs. Open or closed circles represent the relationship between in vitro AQ P‐gp and in vivo R P‐gp or in vitro AQ BCRP and in vivo R bcrp , respectively. In vitro AQ values were cited from our previous report (Kawahara et al, manuscript in revision). Key: 1, ciprofloxacin; 2, nitrofurantoin; 3, topotecan; 4, sulfasalazine. F (˗): False negative, F (+): False positive, T (˗): True negative, T (+): True positive

Techniques Used: In Vitro, In Vivo

Comparison between in vitro AQ and in vivo rate of contribution ( R ) for BCRP and P‐gp
Figure Legend Snippet: Comparison between in vitro AQ and in vivo rate of contribution ( R ) for BCRP and P‐gp

Techniques Used: In Vitro, In Vivo

Related Articles

Incubation:

Article Title: Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system.
Article Snippet: Caco-2 cells are widely used as an in vitro intestinal model.. However, the expression levels of the drugmetabolizing enzymes CYP3A4 and UGT1A1 are lower in these cells than in intestinal cells.. Furthermore, the majority of prodrugs in use today are ester-containing, and carboxylesterase (CES) 1 and CES2 are among the enzymes that process the prodrugs into drugs.

High Performance Liquid Chromatography:

Article Title: Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system.
Article Snippet: Caco-2 cells are widely used as an in vitro intestinal model.. However, the expression levels of the drugmetabolizing enzymes CYP3A4 and UGT1A1 are lower in these cells than in intestinal cells.. Furthermore, the majority of prodrugs in use today are ester-containing, and carboxylesterase (CES) 1 and CES2 are among the enzymes that process the prodrugs into drugs.

Concentration Assay:

Article Title: Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system.
Article Snippet: Caco-2 cells are widely used as an in vitro intestinal model.. However, the expression levels of the drugmetabolizing enzymes CYP3A4 and UGT1A1 are lower in these cells than in intestinal cells.. Furthermore, the majority of prodrugs in use today are ester-containing, and carboxylesterase (CES) 1 and CES2 are among the enzymes that process the prodrugs into drugs.



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