mnk2 (Carna Inc)
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96
Structured Review
Carna Inc
mnk2
Mnk2, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/02-146/MNK2/pm30824167-436-10-14
Average 96 stars, based on 4 article reviews
Mnk2, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/02-146/MNK2/pm30824167-436-10-14
Average 96 stars, based on 4 article reviews
mnk2 - by Bioz Stars,
2026-09
96/100 stars
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Related Articles
Activity Assay:Article Title: Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors. Article Snippet: Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209.. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways.. A series of pyridone−aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Kinase Assay:Article Title: Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors. Article Snippet: Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209.. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways.. A series of pyridone−aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Inhibition:Article Title: Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions Article Snippet: .. GA-017 GA-002 GA-017 GA-002 GA-017 GA-002 GA-017 GA-002 ABL -0.9 CK1δ 3.7 ABL [E255K] -3.4 CK1ε 3.6 ABL [T315I] -1.5 CK2α1/β -4.2 ACK -0.3 CK2α2/β -1.3 ALK 1.0 CLK1 0.7 ALK [C1156Y] 2.3 CLK2 1.6 ALK [F1174L] -0.9 CLK3 -1.4 ALK [G1202R] -1.5 COT_Cascade -1.8 ALK [G1269A] 0.4 CRIK -4.1 ALK [L1152insT] 0.4 DAPK1 -1.6 ALK [L1196M] 3.0 DCAMKL2 -8.9 ALK [R1275Q] 4.8 DLK_Cascade 0.4 EML4-ALK -4.5 DYRK1A -4.7 NPM1-ALK -0.4 DYRK1B -5.1 ARG -0.2 DYRK2 -0.2 AXL 1.3 DYRK3 1.6 BLK 6.0 EEF2K 1.1 BMX 3.0 Erk1 -2.7 BRK -3.0 Erk2 -10.1 BTK -0.2 Erk5 -1.7 BTK [C481S] -1.8 GSK3α 2.8 CSK -4.9 GSK3β 8.6 DDR1 -0.9 Haspin -0.2 DDR2 0.1 HGK 3.8 EGFR 4.5 HIPK1 6.3 EGFR [d746-750] -0.6 HIPK2 2.1 EGFR [d746-750/T790M] -0.8 HIPK3 2.5 EGFR [L858R] 0.5 HIPK4 1.5 EGFR [L861Q] 0.4 HPK1 17.1 EGFR [T790M] 1.5 IKKα 0.7 EGFR [T790M/L858R] 0.1 IKKβ -0.9 EPHA1 -1.2 IKKε -0.4 EPHA2 3.9 IRAK1 -0.6 EPHA3 0.6 IRAK4 -0.4 EPHA4 0.3 JNK1 -2.4 EPHA5 -3.3 JNK2 -4.8 EPHA6 1.5 JNK3 -5.0 EPHA7 -0.5 LATS2 95.6 93.8 4.57±0.21 4.09±0.47 EPHA8 -0.5 LOK 1.0 EPHB1 -1.0 MAP2K1_Cascade 2.9 EPHB2 1.5 MAP2K2_Cascade -1.7 EPHB3 0.6 MAP2K3_Cascade -2.5 EPHB4 0.2 MAP2K4_Cascade 0.9 FAK -3.8 MAP2K5_Cascade 0.1 FER -2.3 MAP2K6_Cascade 2.7 FES 1.2 MAP2K7_Cascade -9.1 FGFR1 6.1 MAP3K1_Cascade 1.9 FGFR1 [V561M] 10.8 MAP3K2_Cascade -2.8 FGFR2 7.7 MAP3K3_Cascade 3.7 FGFR2 [V564I] -2.7 MAP3K4_Cascade -2.3 FGFR3 2.2 MAP3K5_Cascade 4.0 FGFR3 [K650E] 1.3 MAP4K2 1.4 FGFR3 [K650M] 4.2 MAPKAPK2 -0.7 FGFR3 [V555L] -0.1 MAPKAPK3 -6.0 FGFR3 [V555M] 0.7 MAPKAPK5 -8.0 FGFR4 3.3 MARK1 -2.5 FGFR4 [N535K] 3.1 MARK2 -5.8 FGFR4 [V550E] 1.5 MARK3 -16.8 FGFR4 [V550L] 3.5 MARK4 -2.4 FGR 1.1 MELK 0.7 FLT1 2.5 MINK -1.0 FLT3 6.0 MLK1_Cascade 5.1 FLT4 6.1 MLK2_Cascade 6.2 FMS -4.4 MLK3_Cascade 9.4 FRK 0.5 MNK1 0.4 FYN [isoform a] 0.5 Mobility Shift:Article Title: Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions Article Snippet: .. GA-017 GA-002 GA-017 GA-002 GA-017 GA-002 GA-017 GA-002 ABL -0.9 CK1δ 3.7 ABL [E255K] -3.4 CK1ε 3.6 ABL [T315I] -1.5 CK2α1/β -4.2 ACK -0.3 CK2α2/β -1.3 ALK 1.0 CLK1 0.7 ALK [C1156Y] 2.3 CLK2 1.6 ALK [F1174L] -0.9 CLK3 -1.4 ALK [G1202R] -1.5 COT_Cascade -1.8 ALK [G1269A] 0.4 CRIK -4.1 ALK [L1152insT] 0.4 DAPK1 -1.6 ALK [L1196M] 3.0 DCAMKL2 -8.9 ALK [R1275Q] 4.8 DLK_Cascade 0.4 EML4-ALK -4.5 DYRK1A -4.7 NPM1-ALK -0.4 DYRK1B -5.1 ARG -0.2 DYRK2 -0.2 AXL 1.3 DYRK3 1.6 BLK 6.0 EEF2K 1.1 BMX 3.0 Erk1 -2.7 BRK -3.0 Erk2 -10.1 BTK -0.2 Erk5 -1.7 BTK [C481S] -1.8 GSK3α 2.8 CSK -4.9 GSK3β 8.6 DDR1 -0.9 Haspin -0.2 DDR2 0.1 HGK 3.8 EGFR 4.5 HIPK1 6.3 EGFR [d746-750] -0.6 HIPK2 2.1 EGFR [d746-750/T790M] -0.8 HIPK3 2.5 EGFR [L858R] 0.5 HIPK4 1.5 EGFR [L861Q] 0.4 HPK1 17.1 EGFR [T790M] 1.5 IKKα 0.7 EGFR [T790M/L858R] 0.1 IKKβ -0.9 EPHA1 -1.2 IKKε -0.4 EPHA2 3.9 IRAK1 -0.6 EPHA3 0.6 IRAK4 -0.4 EPHA4 0.3 JNK1 -2.4 EPHA5 -3.3 JNK2 -4.8 EPHA6 1.5 JNK3 -5.0 EPHA7 -0.5 LATS2 95.6 93.8 4.57±0.21 4.09±0.47 EPHA8 -0.5 LOK 1.0 EPHB1 -1.0 MAP2K1_Cascade 2.9 EPHB2 1.5 MAP2K2_Cascade -1.7 EPHB3 0.6 MAP2K3_Cascade -2.5 EPHB4 0.2 MAP2K4_Cascade 0.9 FAK -3.8 MAP2K5_Cascade 0.1 FER -2.3 MAP2K6_Cascade 2.7 FES 1.2 MAP2K7_Cascade -9.1 FGFR1 6.1 MAP3K1_Cascade 1.9 FGFR1 [V561M] 10.8 MAP3K2_Cascade -2.8 FGFR2 7.7 MAP3K3_Cascade 3.7 FGFR2 [V564I] -2.7 MAP3K4_Cascade -2.3 FGFR3 2.2 MAP3K5_Cascade 4.0 FGFR3 [K650E] 1.3 MAP4K2 1.4 FGFR3 [K650M] 4.2 MAPKAPK2 -0.7 FGFR3 [V555L] -0.1 MAPKAPK3 -6.0 FGFR3 [V555M] 0.7 MAPKAPK5 -8.0 FGFR4 3.3 MARK1 -2.5 FGFR4 [N535K] 3.1 MARK2 -5.8 FGFR4 [V550E] 1.5 MARK3 -16.8 FGFR4 [V550L] 3.5 MARK4 -2.4 FGR 1.1 MELK 0.7 FLT1 2.5 MINK -1.0 FLT3 6.0 MLK1_Cascade 5.1 FLT4 6.1 MLK2_Cascade 6.2 FMS -4.4 MLK3_Cascade 9.4 FRK 0.5 MNK1 0.4 FYN [isoform a] 0.5 |
