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cefsulodin sodium salt hydrate  (Chem Impex International)


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    Structured Review

    Chem Impex International cefsulodin sodium salt hydrate
    Population PK estimated degradation half-lives (i.e., posthoc estimates) of β-lactams and β-lactamase inhibitors at different pH values in CA-MHB at 36°C a , b , c
    Cefsulodin Sodium Salt Hydrate, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/01573/Cefsulodin+sodium+salt+hydrate/pmc10916406-154-5-23
    Average 95 stars, based on 1 article reviews
    cefsulodin sodium salt hydrate - by Bioz Stars, 2026-09
    95/100 stars

    Images

    1) Product Images from "Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation"

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation

    Journal: Antimicrobial Agents and Chemotherapy

    doi: 10.1128/aac.01399-23

    Population PK estimated degradation half-lives (i.e., posthoc estimates) of β-lactams and β-lactamase inhibitors at different pH values in CA-MHB at 36°C a , b , c
    Figure Legend Snippet: Population PK estimated degradation half-lives (i.e., posthoc estimates) of β-lactams and β-lactamase inhibitors at different pH values in CA-MHB at 36°C a , b , c

    Techniques Used:

    Optimal dosing schemes with one supplement dose at 9 h
    Figure Legend Snippet: Optimal dosing schemes with one supplement dose at 9 h

    Techniques Used:

    Optimal dosing schemes with two supplement doses e , f
    Figure Legend Snippet: Optimal dosing schemes with two supplement doses e , f

    Techniques Used:

    Thermal degradation half-lives of ten β-lactam antibiotics and three β-lactamase inhibitors in different matrices relevant for in vitro infection model experiments and susceptibility testing at different temperatures and pH c , d
    Figure Legend Snippet: Thermal degradation half-lives of ten β-lactam antibiotics and three β-lactamase inhibitors in different matrices relevant for in vitro infection model experiments and susceptibility testing at different temperatures and pH c , d

    Techniques Used: In Vitro, Infection

    Fraction of drug remaining in agar incubated at 37 and 4°C for different durations a
    Figure Legend Snippet: Fraction of drug remaining in agar incubated at 37 and 4°C for different durations a

    Techniques Used: Incubation

    Related Articles

    In Vitro:

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: The CA-MHB and CA-MHA were obtained from Becton, Dickinson and Company (Sparks, MD).

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: Ceftazidime pentahydrate, cefepime dihydrochloride monohydrate, cefsulodin sodium salt hydrate, piperacillin sodium salt, ticarcillin disodium salt, aztreonam, and tazobactam sodium salt were purchased from Chem-Impex International (Wood Dale, IL) and sulbactam from TCI America (Portland, OR).

    Infection:

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: The CA-MHB and CA-MHA were obtained from Becton, Dickinson and Company (Sparks, MD).

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: Ceftazidime pentahydrate, cefepime dihydrochloride monohydrate, cefsulodin sodium salt hydrate, piperacillin sodium salt, ticarcillin disodium salt, aztreonam, and tazobactam sodium salt were purchased from Chem-Impex International (Wood Dale, IL) and sulbactam from TCI America (Portland, OR).

    Incubation:

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: The CA-MHB and CA-MHA were obtained from Becton, Dickinson and Company (Sparks, MD).

    Article Title: Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation
    Article Snippet: Ceftazidime pentahydrate, cefepime dihydrochloride monohydrate, cefsulodin sodium salt hydrate, piperacillin sodium salt, ticarcillin disodium salt, aztreonam, and tazobactam sodium salt were purchased from Chem-Impex International (Wood Dale, IL) and sulbactam from TCI America (Portland, OR).



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    Figure 3. THC decreases MMP25 while elevating <t>TIMP2</t> protein expression in CE of SIV-infected RMs. Whole colon tissue sections were immunostained for MMP25 (A) (green) and TIMP2 (E) (red) and DAPI for nuclear staining (blue). Note the increased MMP25 (A) and decreased TIMP2 (E) protein expression, specifically in CE of VEH/SIV (n = 5) compared with THC/SIV (n = 5) and control (n = 5) RMs. Representative immunofluorescence images were captured using a Zeiss confocal microscope at 20× original magnification. Scale bars: 50 μm. The demarcation of CE regions excluding the lamina propria compart- ment using the freehand tool in HALO (B). Differences in MMP25 (C) and TIMP2 (F) signal intensity between groups were analyzed using 1-way ANOVA employing the Prism v9 (GraphPad Prism). A P value of <0.05 was considered significant. Data represent mean ± SEM. STRING v 11.0 software was used to predict the MMP25 protein-protein interactions with other proteins (D). Each node represents all the proteins produced by a single protein-coding gene locus. Edges represent protein-protein associations.
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    Figure 3. THC decreases MMP25 while elevating <t>TIMP2</t> protein expression in CE of SIV-infected RMs. Whole colon tissue sections were immunostained for MMP25 (A) (green) and TIMP2 (E) (red) and DAPI for nuclear staining (blue). Note the increased MMP25 (A) and decreased TIMP2 (E) protein expression, specifically in CE of VEH/SIV (n = 5) compared with THC/SIV (n = 5) and control (n = 5) RMs. Representative immunofluorescence images were captured using a Zeiss confocal microscope at 20× original magnification. Scale bars: 50 μm. The demarcation of CE regions excluding the lamina propria compart- ment using the freehand tool in HALO (B). Differences in MMP25 (C) and TIMP2 (F) signal intensity between groups were analyzed using 1-way ANOVA employing the Prism v9 (GraphPad Prism). A P value of <0.05 was considered significant. Data represent mean ± SEM. STRING v 11.0 software was used to predict the MMP25 protein-protein interactions with other proteins (D). Each node represents all the proteins produced by a single protein-coding gene locus. Edges represent protein-protein associations.
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    Image Search Results


    Figure 3. THC decreases MMP25 while elevating TIMP2 protein expression in CE of SIV-infected RMs. Whole colon tissue sections were immunostained for MMP25 (A) (green) and TIMP2 (E) (red) and DAPI for nuclear staining (blue). Note the increased MMP25 (A) and decreased TIMP2 (E) protein expression, specifically in CE of VEH/SIV (n = 5) compared with THC/SIV (n = 5) and control (n = 5) RMs. Representative immunofluorescence images were captured using a Zeiss confocal microscope at 20× original magnification. Scale bars: 50 μm. The demarcation of CE regions excluding the lamina propria compart- ment using the freehand tool in HALO (B). Differences in MMP25 (C) and TIMP2 (F) signal intensity between groups were analyzed using 1-way ANOVA employing the Prism v9 (GraphPad Prism). A P value of <0.05 was considered significant. Data represent mean ± SEM. STRING v 11.0 software was used to predict the MMP25 protein-protein interactions with other proteins (D). Each node represents all the proteins produced by a single protein-coding gene locus. Edges represent protein-protein associations.

    Journal: JCI insight

    Article Title: Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection.

    doi: 10.1172/jci.insight.167903

    Figure Lengend Snippet: Figure 3. THC decreases MMP25 while elevating TIMP2 protein expression in CE of SIV-infected RMs. Whole colon tissue sections were immunostained for MMP25 (A) (green) and TIMP2 (E) (red) and DAPI for nuclear staining (blue). Note the increased MMP25 (A) and decreased TIMP2 (E) protein expression, specifically in CE of VEH/SIV (n = 5) compared with THC/SIV (n = 5) and control (n = 5) RMs. Representative immunofluorescence images were captured using a Zeiss confocal microscope at 20× original magnification. Scale bars: 50 μm. The demarcation of CE regions excluding the lamina propria compart- ment using the freehand tool in HALO (B). Differences in MMP25 (C) and TIMP2 (F) signal intensity between groups were analyzed using 1-way ANOVA employing the Prism v9 (GraphPad Prism). A P value of <0.05 was considered significant. Data represent mean ± SEM. STRING v 11.0 software was used to predict the MMP25 protein-protein interactions with other proteins (D). Each node represents all the proteins produced by a single protein-coding gene locus. Edges represent protein-protein associations.

    Article Snippet: Immunofluorescence studies for the detection of MMP25 (1:50) (Abcam; ab56309), TIMP2 (1:100) (Novus Biologicals; NBP2-01573), CD47 (1:200) (Mybiosource.com; MBS8106360), MPO (1:6,000) (Abcam; A0398), and CD11b (1:100) (Abcam; ab34216) were performed as described previously (16).

    Techniques: Expressing, Infection, Staining, Control, Immunofluorescence, Microscopy, Software, Protein-Protein interactions, Produced

    Figure 8. Impact of THC enhancement of MMP25-AS1/MMP25 interaction on neutrophil transendothelial/ transepithelial migration in HIV/SIV infection. At the transcriptional level, MMP25-AS1 directly interacts with MMP25, a matrix metalloproteinase known to enhance the activation of neutrophils and promote inflammation and barrier disruption, allowing microbial translocation. Increased TIMP2 expression results in a further decrease of MMP25 expression at the protein level. The reduction of MMP25 expression also results in a concomitant decrease in CXCL5 and CCL15 expression, 2 potent neutrophil chemoattractants activated by MMP25-mediated cleavage, thus highlighting THC’s potential to block a feed-forward mechanism for neutrophil recruitment. Importantly, THC administration to SIV-infected RMs on long-term cART successfully reduced MMP25 expression in JE of chronically SIV-infected RMs, while concurrently preserving the expression of its natural antisense lncRNA regulator MMP25- AS1. From a therapeutic standpoint, long-term low-dose THC administered as an adjunct to cART represents a potentially safe and effective intervention to dampen chronic immune activation and inflammation, a major driver of HIV-associated comorbidities in virally suppressed PLWH.

    Journal: JCI insight

    Article Title: Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection.

    doi: 10.1172/jci.insight.167903

    Figure Lengend Snippet: Figure 8. Impact of THC enhancement of MMP25-AS1/MMP25 interaction on neutrophil transendothelial/ transepithelial migration in HIV/SIV infection. At the transcriptional level, MMP25-AS1 directly interacts with MMP25, a matrix metalloproteinase known to enhance the activation of neutrophils and promote inflammation and barrier disruption, allowing microbial translocation. Increased TIMP2 expression results in a further decrease of MMP25 expression at the protein level. The reduction of MMP25 expression also results in a concomitant decrease in CXCL5 and CCL15 expression, 2 potent neutrophil chemoattractants activated by MMP25-mediated cleavage, thus highlighting THC’s potential to block a feed-forward mechanism for neutrophil recruitment. Importantly, THC administration to SIV-infected RMs on long-term cART successfully reduced MMP25 expression in JE of chronically SIV-infected RMs, while concurrently preserving the expression of its natural antisense lncRNA regulator MMP25- AS1. From a therapeutic standpoint, long-term low-dose THC administered as an adjunct to cART represents a potentially safe and effective intervention to dampen chronic immune activation and inflammation, a major driver of HIV-associated comorbidities in virally suppressed PLWH.

    Article Snippet: Immunofluorescence studies for the detection of MMP25 (1:50) (Abcam; ab56309), TIMP2 (1:100) (Novus Biologicals; NBP2-01573), CD47 (1:200) (Mybiosource.com; MBS8106360), MPO (1:6,000) (Abcam; A0398), and CD11b (1:100) (Abcam; ab34216) were performed as described previously (16).

    Techniques: Migration, Infection, Activation Assay, Disruption, Translocation Assay, Expressing, Blocking Assay, Preserving