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l ap4  (Tocris)


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Bioz Manufacturer Symbol Tocris manufactures this product  
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    Structured Review

    Tocris l ap4
    L Ap4, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 369 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/0103/L-AP4/pm36947616-256-15-22
    Average 96 stars, based on 369 article reviews
    l ap4 - by Bioz Stars, 2026-09
    96/100 stars

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    Related Articles

    other:

    Article Title: A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa
    Article Snippet: L-AP4 (50 nM and 10 μM; Tocris Bioscience) was applied via the bath solution.

    Blocking Assay:

    Article Title: A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa
    Article Snippet: Pairs were visually identified using IR-DIC microscopy (Zeiss LSM-510, 40x/1.0 NA objective). .. Recordings were made in AMES media supplemented with strychnine hydrochloride (3 μM, Sigma Aldrich) and picrotoxin (100 μM, Abcam) to block inhibitory synaptic transmission, and L-AP4 (10 μM, Tocris Bioscience) to minimize synaptic input from other RBCs presynaptic to the recorded AIIs ( ). ..

    Transmission Assay:

    Article Title: A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa
    Article Snippet: Pairs were visually identified using IR-DIC microscopy (Zeiss LSM-510, 40x/1.0 NA objective). .. Recordings were made in AMES media supplemented with strychnine hydrochloride (3 μM, Sigma Aldrich) and picrotoxin (100 μM, Abcam) to block inhibitory synaptic transmission, and L-AP4 (10 μM, Tocris Bioscience) to minimize synaptic input from other RBCs presynaptic to the recorded AIIs ( ). ..

    Article Title: Flp-recombinase mouse line for genetic manipulation of ipRGCs
    Article Snippet: .. Synaptic transmission was blocked with 100μM DNQX (Tocris), 2μM L-AP4 (Tocris), 100μM picrotoxin (Sigma-Aldrich), and 20μM strychnine (Sigma-Aldrich) in Ames’ medium. .. 500nM tetrodotoxin (TTX) citrate (Tocris) was added to the synaptic blocker solution for voltage-clamp experiments.



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    Image Search Results


    METTL1-deficient MSCs inhibit lipid synthesis in hepatocytes. (A) Representative images of Nile Red staining in hepatocytes co-cultured with MSC shGFP and MSC shMETTL1 following treatment with FFA (Scale bar = 20 μm). (B) Measurement of TG content in hepatocytes in the indicated groups. (C, D) Western blot analysis of lipid metabolism-related gene expression (FASN, SREBP1, SCD1) in the indicated groups. (E, F) qPCR analysis of lipid synthesis gene expression ( Fasn, Scd1, Srebp1, Fads1 and Acaca ) in AML12 and HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 . For all statistical graphs, data are presented as mean ± S.E.M, with statistical significance is indicated in the figure.

    Journal: Stem Cells Translational Medicine

    Article Title: METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion

    doi: 10.1093/stcltm/szag016

    Figure Lengend Snippet: METTL1-deficient MSCs inhibit lipid synthesis in hepatocytes. (A) Representative images of Nile Red staining in hepatocytes co-cultured with MSC shGFP and MSC shMETTL1 following treatment with FFA (Scale bar = 20 μm). (B) Measurement of TG content in hepatocytes in the indicated groups. (C, D) Western blot analysis of lipid metabolism-related gene expression (FASN, SREBP1, SCD1) in the indicated groups. (E, F) qPCR analysis of lipid synthesis gene expression ( Fasn, Scd1, Srebp1, Fads1 and Acaca ) in AML12 and HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 . For all statistical graphs, data are presented as mean ± S.E.M, with statistical significance is indicated in the figure.

    Article Snippet: Human HepG2 cells (CL-0103) and mouse AML12 cells (CL-0602) were also sourced from Procell (China) and cultured in DMEM supplemented with 10% FBS and 1% penicillin/streptomycin.

    Techniques: Staining, Cell Culture, Western Blot, Gene Expression

    NAMPT/SIRT1/SREBP1 mediates the protective effects of METTL1-deficient MSCs in MASLD. (A-C) Representative images of IF staining for NAMPT, SIRT1 and SREBP1 in HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 cells after treatment with FFA (Scale bar = 20 μm). (D, E) Western blot analysis of NAMPT, SIRT1 and SREBP1 expression in HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 cells following FFA treatment. (F) The NAD+ content was measured in the indicated cells. (G-I) Representative images of IF staining for NAMPT, SIRT1 and SREBP1 in liver tissues from mice transplanted with MSC shGFP and MSC shMETTL1 cells after 16 weeks of HFD feeding (Scale bar = 100 μm). (J, K) Western blot analysis of NAMPT, SIRT1, and SREBP1 expression in liver tissues from mice transplanted with MSC shGFP and MSC shMETTL1 cells after 16 weeks of HFD feeding. (L) The NAD+ content was measured in the indicated mouse liver tissues. For all statistical graphs, data are presented as mean ± S.E.M., with statistical significance indicated in the figure.

    Journal: Stem Cells Translational Medicine

    Article Title: METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion

    doi: 10.1093/stcltm/szag016

    Figure Lengend Snippet: NAMPT/SIRT1/SREBP1 mediates the protective effects of METTL1-deficient MSCs in MASLD. (A-C) Representative images of IF staining for NAMPT, SIRT1 and SREBP1 in HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 cells after treatment with FFA (Scale bar = 20 μm). (D, E) Western blot analysis of NAMPT, SIRT1 and SREBP1 expression in HepG2 cells co-cultured with MSC shGFP and MSC shMETTL1 cells following FFA treatment. (F) The NAD+ content was measured in the indicated cells. (G-I) Representative images of IF staining for NAMPT, SIRT1 and SREBP1 in liver tissues from mice transplanted with MSC shGFP and MSC shMETTL1 cells after 16 weeks of HFD feeding (Scale bar = 100 μm). (J, K) Western blot analysis of NAMPT, SIRT1, and SREBP1 expression in liver tissues from mice transplanted with MSC shGFP and MSC shMETTL1 cells after 16 weeks of HFD feeding. (L) The NAD+ content was measured in the indicated mouse liver tissues. For all statistical graphs, data are presented as mean ± S.E.M., with statistical significance indicated in the figure.

    Article Snippet: Human HepG2 cells (CL-0103) and mouse AML12 cells (CL-0602) were also sourced from Procell (China) and cultured in DMEM supplemented with 10% FBS and 1% penicillin/streptomycin.

    Techniques: Staining, Cell Culture, Western Blot, Expressing