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akt3  (Carna Inc)


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    Carna Inc akt3
    Akt3, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/01-103/AKT3/10__1158_slash_0008___5472__can___17___0484-85-67-69
    Average 96 stars, based on 2 article reviews
    akt3 - by Bioz Stars, 2026-09
    96/100 stars

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    Article Title: PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
    Article Snippet: 1 PI-273, a substrate-competitive, specific small molecule inhibitor of PI4KIIα, inhibits the growth of breast cancer cells Running title: The First PI4KIIα Substrate-Competitive Specific Inhibitor Jiangmei Li1, 7 #, Zhen Gao1, 6 #, Dan Zhao2, 6#, Lunfeng Zhang1,6, Xinhua Qiao1, 6, Yingying Zhao1, 7, Hong Ding2, Panpan Zhang 5 ,6,7, Junyan Lu2, Jia Liu7, Hualiang Jiang2, Cheng Luo2 ,4*, Chang Chen1, 3, 6* 1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China 2Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China 3Beijing Institute for Brain Disorders, No. 10 Xitoutiao, You An Men, Beijing, 100069, China 4The State Key Laboratory of Toxicology and Medical Countermeasures, Academy of Military Medical Science, Beijing, China 5 Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China 6University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing, 100049, China 7Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China # These authors contributed equally to this work.. Running title: The First PI4KIIα Substrate-competitive Specific Inhibitor Key words: Phosphatidylinositol 4-kinase IIα; Substrate-competitive small-molecule inhibitor; Virtual screening; Breast cancer Grant Support: This research was supported by National Key R&D Program of China (2017YFA0504000, 2016YFC0903100 to C. Chen), Personalized Medicines-Molecular Signature-based Drug Discovery and Development, the Strategic Priority Research Program of Research. on August 22, 2017.. © 2017 American Association for Cancercancerres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.



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    Image Search Results


    (a) Thermostability profile of AVA-1-1-C3 as a representative protein, as determined by differential scanning fluorimetry. (b-g) Cytotoxicity of primary human cells following 48-hour exposure to AVA-1-1-C3 or an equivalent concentration of bovine serum albumin (BSA), evaluated using the CellTiter-Glo® (CTG) luminescent cell viability assay. Cell types included human epithelial keratinocytes (HEK, b), human dermal fibroblasts (HDF, c), human follicle dermal papilla cells (HFDPC, d), human renal cortical epithelial cells (HRCEPC, e), human skeletal muscle cells (HSKMC, f), and human dermal microvascular endothelial cells (HDMEC, g). No significant differences in cell viability were observed. Data in (b-g) represents mean ± s.d. and are representative of two experimental replicates.

    Journal: bioRxiv

    Article Title: Development of high-affinity, single-domain protein binders for neutralizing household allergens

    doi: 10.1101/2025.08.03.668213

    Figure Lengend Snippet: (a) Thermostability profile of AVA-1-1-C3 as a representative protein, as determined by differential scanning fluorimetry. (b-g) Cytotoxicity of primary human cells following 48-hour exposure to AVA-1-1-C3 or an equivalent concentration of bovine serum albumin (BSA), evaluated using the CellTiter-Glo® (CTG) luminescent cell viability assay. Cell types included human epithelial keratinocytes (HEK, b), human dermal fibroblasts (HDF, c), human follicle dermal papilla cells (HFDPC, d), human renal cortical epithelial cells (HRCEPC, e), human skeletal muscle cells (HSKMC, f), and human dermal microvascular endothelial cells (HDMEC, g). No significant differences in cell viability were observed. Data in (b-g) represents mean ± s.d. and are representative of two experimental replicates.

    Article Snippet: For in vitro toxicity studies, primary cells including human dermal fibroblasts (HDF, Cell Applications, Cat# 106K-05a, lot 1632), human epidermal keratinocytes (HEK, Cell Applications, Cat# 102-05a, lot 2146), human dermal microvascular endothelial cells (HDMEC, PromoCell, Cat# C-12210, lot 483Z001.3), human skeletal muscle cells (HSKMC, Cell Applications, Cat# 150K-05a, lot 3507), and human renal cortical epithelial cells (HRCEpC, Promocell, Cat# C-12660, lot 501Z019.23).

    Techniques: Concentration Assay, Cell Viability Assay