reactions with akt1 (Carna Inc)
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Carna Inc
reactions with akt1
Reactions With Akt1, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/01-101/AKT1/10__1021_slash_jm300276x-690-0-3
Average 96 stars, based on 19 article reviews
Reactions With Akt1, supplied by Carna Inc, used in various techniques. Bioz Stars score: 96/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/01-101/AKT1/10__1021_slash_jm300276x-690-0-3
Average 96 stars, based on 19 article reviews
reactions with akt1 - by Bioz Stars,
2026-09
96/100 stars
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Activity Assay:Article Title: The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER CK1 Thermo Fisher Scientific Cat# PV3825 CK2 alpha Thermo Fisher Scientific Cat# PV3248 DYRK1A Thermo Fisher Scientific Cat# PV3785 DYRK1B Thermo Fisher Scientific Cat# PV4649 GSK3 alpha Thermo Fisher Scientific Cat# PV3270 GSK3 beta Thermo Fisher Scientific Cat# PV3365 IKBKB Thermo Fisher Scientific Cat# PV3826 MAPK1 Thermo Fisher Scientific Cat# PV3313 MAPK3 Thermo Fisher Scientific Cat# PV3311 MAPK8 Thermo Fisher Scientific Cat# PV3319 MAPK9 Thermo Fisher Scientific Cat# PV3620 MAPK10 Thermo Fisher Scientific Cat# PV4563 MAPK11 Thermo Fisher Scientific Cat# PV3679 MAPK12 Thermo Fisher Scientific Cat# PV3654 MAPK13 Thermo Fisher Scientific Cat# PV3656 MAPK14 Thermo Fisher Scientific Cat# PV3304 MAP3K11 Thermo Fisher Scientific Cat# PV3788 MARK1 Thermo Fisher Scientific Cat# PV4395 MARK2 Thermo Fisher Scientific Cat# PV3878 MLCK Thermo Fisher Scientific Cat# PV3835 PAK1 Thermo Fisher Scientific Cat# PV3820 PI3K Thermo Fisher Scientific Cat# PV4788 PKA Thermo Fisher Scientific Cat# P2912 PKC alpha Thermo Fisher Scientific Cat# P2232 PKCa Carna Bioscience Cat# 01-127 PKC delta Thermo Fisher Scientific Cat# P2293 PRKG1 Thermo Fisher Scientific Cat# PV4340 PRKG2 Thermo Fisher Scientific Cat# PV3973 RAF1(cRAF)Y340DY341D Thermo Fisher Scientific Cat# PV3805 RET Thermo Fisher Scientific Cat# PV3819 ROCK2 Thermo Fisher Scientific Cat# PV3759 RSK1 Thermo Fisher Scientific Cat# PV3680 LKB1 Carna Bioscience Cat# 02-119 EGFR Thermo Fisher Scientific Cat# PV3872 EphA5 Thermo Fisher Scientific Cat# PV3840 FGFR1 Thermo Fisher Scientific Cat# PV3146 FGFR3 Thermo Fisher Scientific Cat# PV3145 MUSK Thermo Fisher Scientific Cat# PV3834 PDGFR alpha Thermo Fisher Scientific Cat# PV3811 Yes Thermo Fisher Scientific Cat# P3078 EphB1 Thermo Fisher Scientific Cat# PV3786 EphB2 Thermo Fisher Scientific Cat# Article Title: Substituted isoquinolines as rock kinase inhibitors Article Snippet: Dose-response curves for compounds of the present invention were determined using a fluorescence coupling enzymatic assay using purified C-terminal truncated human ROCK1 catalytic domain (amino acids 1-477 of accession number NP_005397.1) fused to GST (Carna BioSciences, Catalog #01-109) and purified C-terminal truncated human ROCK2 enzyme kinase domain (amino acids 1-553 of accession number NP_004841.2) fused to GST BioSciences, Catalog #01-110). .. In addition, full length cGMP-dependent protein kinase 1 (PKG or PRKG1; amino acids 1-686 of accession number NP_006249.1) fused to GST (Carna BioSciences, Catalog #01-142), full length PKACα (PRKACA; amino acids 1-351 of accession number NP_002721.1) fused to GST (Carna BioSciences, Catalog #01-127), and C-terminal truncated Recombinant:Article Title: Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. Article Snippet: .. Oncogenic forms Article Title: Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. Article Snippet: Akt has emerged as an exciting target in oncology due to its critical roles in proliferation, survival, metabolism, metastasis, and invasion in tumor cells.. Herein, we describe the discovery and optimization of a series of ATP-competitive Akt inhibitors that possess new chemical scaffolds and exhibit potent enzymatic activities and improved in vivo pharmacokinetic profiles.. Remarkably, NTQ1062 (compound 22b) exhibited potent antitumor efficacies in vitro and in vivo, which was accomplished through the optimization of the hinge binder region and the linkage. Control:Article Title: Substituted isoquinolines as rock kinase inhibitors Article Snippet: Dose-response curves for compounds of the present invention were determined using a fluorescence coupling enzymatic assay using purified C-terminal truncated human ROCK1 catalytic domain (amino acids 1-477 of accession number NP_005397.1) fused to GST (Carna BioSciences, Catalog #01-109) and purified C-terminal truncated human ROCK2 enzyme kinase domain (amino acids 1-553 of accession number NP_004841.2) fused to GST BioSciences, Catalog #01-110). .. In addition, full length cGMP-dependent protein kinase 1 (PKG or PRKG1; amino acids 1-686 of accession number NP_006249.1) fused to GST (Carna BioSciences, Catalog #01-142), full length PKACα (PRKACA; amino acids 1-351 of accession number NP_002721.1) fused to GST (Carna BioSciences, Catalog #01-127), and C-terminal truncated Incubation:Article Title: Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. Article Snippet: Akt has emerged as an exciting target in oncology due to its critical roles in proliferation, survival, metabolism, metastasis, and invasion in tumor cells.. Herein, we describe the discovery and optimization of a series of ATP-competitive Akt inhibitors that possess new chemical scaffolds and exhibit potent enzymatic activities and improved in vivo pharmacokinetic profiles.. Remarkably, NTQ1062 (compound 22b) exhibited potent antitumor efficacies in vitro and in vivo, which was accomplished through the optimization of the hinge binder region and the linkage. |