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2 4 6 tripyridyl s triazine  (Chem Impex International)


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    Chem Impex International 2 4 6 tripyridyl s triazine
    2 4 6 Tripyridyl S Triazine, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/00295/2%2C4%2C6-Tripyridyl-S-triazine/10__1021_slash_acssuschemeng__1c08638-202-66-67
    Average 95 stars, based on 1 article reviews
    2 4 6 tripyridyl s triazine - by Bioz Stars, 2026-09
    95/100 stars

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    Staining:

    Article Title: Multifunctional Carbon Quantum Dots Prevent Soluble-to-Toxic Transformation of Amyloid and Oxidative Stress
    Article Snippet: Carbon quantum dots (CQDs), depending on their surface functionalization, have found utility across a number of biological applications.. Here, we demonstrate that individual CQDs can serve multifunctional roles, which is a key requisite for the development of drugs for neurodegenerative disorders such as Parkinson’s disease (PD).. Na-citrate-, phenylboronic acid-, and 4-aminophenylboronic acid-derived CQDs were evaluated for their ability to intervene in amyloid-forming trajectories and restore intracellular homeostasis under oxidative stress.

    Fluorescence:

    Article Title: Multifunctional Carbon Quantum Dots Prevent Soluble-to-Toxic Transformation of Amyloid and Oxidative Stress
    Article Snippet: Carbon quantum dots (CQDs), depending on their surface functionalization, have found utility across a number of biological applications.. Here, we demonstrate that individual CQDs can serve multifunctional roles, which is a key requisite for the development of drugs for neurodegenerative disorders such as Parkinson’s disease (PD).. Na-citrate-, phenylboronic acid-, and 4-aminophenylboronic acid-derived CQDs were evaluated for their ability to intervene in amyloid-forming trajectories and restore intracellular homeostasis under oxidative stress.

    Modification:

    Article Title: Multifunctional Carbon Quantum Dots Prevent Soluble-to-Toxic Transformation of Amyloid and Oxidative Stress
    Article Snippet: Carbon quantum dots (CQDs), depending on their surface functionalization, have found utility across a number of biological applications.. Here, we demonstrate that individual CQDs can serve multifunctional roles, which is a key requisite for the development of drugs for neurodegenerative disorders such as Parkinson’s disease (PD).. Na-citrate-, phenylboronic acid-, and 4-aminophenylboronic acid-derived CQDs were evaluated for their ability to intervene in amyloid-forming trajectories and restore intracellular homeostasis under oxidative stress.



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    ( A ) Immunofluorescence of meiotic chromosome spreads with SETX (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( B ) Quantification of pachytene spreads in a (four vehicle mice; n = 237 cells; four ATRi mice; n = 283 cells p=0.00435 measured by Student’s t -test). ( C ) Rad1 cKO and control spreads stained as in ( A ). ( D ) Quantification of pachytene or pachytene-like spreads in ( C ) (four control mice, n = 64 cells; four RAD1 cKO mice, n = 72 cells p=0.00286 measured by Student’s t -test). ( E ) Immunofluorescence of meiotic chromosome spreads with <t>RANBP3</t> (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( F ) Quantification of pachytene spreads in e (three vehicle mice, n = 174 cells; three ATRi mice, n = 167 cells p=0.048 measured by Student’s t -test). ( G ) Rad1 cKO and control spreads stained as in ( E ). ( H ) Quantification of pachytene or pachytene-like spreads in ( G ) (four control mice, n = 96 cells; four cKO mice, n = 99 cells p=0.0039 measured by Student’s t -test).
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    Immunomodulatory effects of emu-let-7-5p in the transfected RAW264.7 macrophages. (A) qPCR analysis of the levels of emu-let-7-5p in mimics-transfected cells. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (B) NO secretion post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (C) qPCR analysis of inos expression post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (D) qPCR analysis of the expression of pro- and anti-inflammatory cytokine genes post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; ** p < 0.01, *** p < 0.001. Data for the final analysis are from three independent experiments. (E) Determination of IL-1α and IL-6 levels by ELISA. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (F) qPCR analysis of the expression of key components in the <t>LPS/TLR4</t> signaling pathway post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05, ** p < 0.01. Data for the final analysis are from three independent experiments. (G) Flow cytometry of the expression of CD40, CD86, CD54 and CD80 post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. MFI, mean fluorescence intensity.
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    Immunomodulatory effects of emu-let-7-5p in the transfected RAW264.7 macrophages. (A) qPCR analysis of the levels of emu-let-7-5p in mimics-transfected cells. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (B) NO secretion post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (C) qPCR analysis of inos expression post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (D) qPCR analysis of the expression of pro- and anti-inflammatory cytokine genes post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; ** p < 0.01, *** p < 0.001. Data for the final analysis are from three independent experiments. (E) Determination of IL-1α and IL-6 levels by ELISA. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (F) qPCR analysis of the expression of key components in the <t>LPS/TLR4</t> signaling pathway post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05, ** p < 0.01. Data for the final analysis are from three independent experiments. (G) Flow cytometry of the expression of CD40, CD86, CD54 and CD80 post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. MFI, mean fluorescence intensity.
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    Image Search Results


    ( A ) Immunofluorescence of meiotic chromosome spreads with SETX (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( B ) Quantification of pachytene spreads in a (four vehicle mice; n = 237 cells; four ATRi mice; n = 283 cells p=0.00435 measured by Student’s t -test). ( C ) Rad1 cKO and control spreads stained as in ( A ). ( D ) Quantification of pachytene or pachytene-like spreads in ( C ) (four control mice, n = 64 cells; four RAD1 cKO mice, n = 72 cells p=0.00286 measured by Student’s t -test). ( E ) Immunofluorescence of meiotic chromosome spreads with RANBP3 (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( F ) Quantification of pachytene spreads in e (three vehicle mice, n = 174 cells; three ATRi mice, n = 167 cells p=0.048 measured by Student’s t -test). ( G ) Rad1 cKO and control spreads stained as in ( E ). ( H ) Quantification of pachytene or pachytene-like spreads in ( G ) (four control mice, n = 96 cells; four cKO mice, n = 99 cells p=0.0039 measured by Student’s t -test).

    Journal: eLife

    Article Title: Phosphoproteomics of ATR signaling in mouse testes

    doi: 10.7554/eLife.68648

    Figure Lengend Snippet: ( A ) Immunofluorescence of meiotic chromosome spreads with SETX (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( B ) Quantification of pachytene spreads in a (four vehicle mice; n = 237 cells; four ATRi mice; n = 283 cells p=0.00435 measured by Student’s t -test). ( C ) Rad1 cKO and control spreads stained as in ( A ). ( D ) Quantification of pachytene or pachytene-like spreads in ( C ) (four control mice, n = 64 cells; four RAD1 cKO mice, n = 72 cells p=0.00286 measured by Student’s t -test). ( E ) Immunofluorescence of meiotic chromosome spreads with RANBP3 (green) and SYCP3 (red) from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( F ) Quantification of pachytene spreads in e (three vehicle mice, n = 174 cells; three ATRi mice, n = 167 cells p=0.048 measured by Student’s t -test). ( G ) Rad1 cKO and control spreads stained as in ( E ). ( H ) Quantification of pachytene or pachytene-like spreads in ( G ) (four control mice, n = 96 cells; four cKO mice, n = 99 cells p=0.0039 measured by Student’s t -test).

    Article Snippet: RANBP3 , Bethyl , IHC-00295 , 1:100.

    Techniques: Immunofluorescence, Control, Staining

    ( A ) Quantification of RANBP3 intensity from meiotic spreads separated by animal. ( B ) Example spreads from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( C ) Quantification of RANBP3 at the sex body or sex chromosomes body of control or Rad1 cKO meiotic spreads, respectively. ( D ) Example images. See Materials and methods for more details on quantification. Data derived from 8- to 12-week-old animals, except when noted by postnatal day 14 (PND14).

    Journal: eLife

    Article Title: Phosphoproteomics of ATR signaling in mouse testes

    doi: 10.7554/eLife.68648

    Figure Lengend Snippet: ( A ) Quantification of RANBP3 intensity from meiotic spreads separated by animal. ( B ) Example spreads from mice collected 4 hr after 50 mg/kg treatment with AZ20 or vehicle. ( C ) Quantification of RANBP3 at the sex body or sex chromosomes body of control or Rad1 cKO meiotic spreads, respectively. ( D ) Example images. See Materials and methods for more details on quantification. Data derived from 8- to 12-week-old animals, except when noted by postnatal day 14 (PND14).

    Article Snippet: RANBP3 , Bethyl , IHC-00295 , 1:100.

    Techniques: Control, Derivative Assay

    Journal: eLife

    Article Title: Phosphoproteomics of ATR signaling in mouse testes

    doi: 10.7554/eLife.68648

    Figure Lengend Snippet:

    Article Snippet: RANBP3 , Bethyl , IHC-00295 , 1:100.

    Techniques:

    Immunomodulatory effects of emu-let-7-5p in the transfected RAW264.7 macrophages. (A) qPCR analysis of the levels of emu-let-7-5p in mimics-transfected cells. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (B) NO secretion post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (C) qPCR analysis of inos expression post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (D) qPCR analysis of the expression of pro- and anti-inflammatory cytokine genes post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; ** p < 0.01, *** p < 0.001. Data for the final analysis are from three independent experiments. (E) Determination of IL-1α and IL-6 levels by ELISA. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (F) qPCR analysis of the expression of key components in the LPS/TLR4 signaling pathway post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05, ** p < 0.01. Data for the final analysis are from three independent experiments. (G) Flow cytometry of the expression of CD40, CD86, CD54 and CD80 post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. MFI, mean fluorescence intensity.

    Journal: Frontiers in Veterinary Science

    Article Title: Modulatory Effects of Echinococcus multilocularis emu-let-7-5p on the Immunological Functions of RAW264.7 Macrophages

    doi: 10.3389/fvets.2021.663497

    Figure Lengend Snippet: Immunomodulatory effects of emu-let-7-5p in the transfected RAW264.7 macrophages. (A) qPCR analysis of the levels of emu-let-7-5p in mimics-transfected cells. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (B) NO secretion post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (C) qPCR analysis of inos expression post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m. Data for the final analysis are from three independent experiments. (D) qPCR analysis of the expression of pro- and anti-inflammatory cytokine genes post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; ** p < 0.01, *** p < 0.001. Data for the final analysis are from three independent experiments. (E) Determination of IL-1α and IL-6 levels by ELISA. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. (F) qPCR analysis of the expression of key components in the LPS/TLR4 signaling pathway post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05, ** p < 0.01. Data for the final analysis are from three independent experiments. (G) Flow cytometry of the expression of CD40, CD86, CD54 and CD80 post transfection with emu-let-7-5p. Data are expressed as mean ± s.e.m; * p < 0.05. Data for the final analysis are from three independent experiments. MFI, mean fluorescence intensity.

    Article Snippet: The relative expression levels of 19 protein-coding genes were analyzed by qPCR, including inos , 7 cytokine genes ( il-4, il-10, tnf- α, il-1 α, il-1 β, il-6 , and il-12B ) and 11 key genes in the LPS/TLR4 pathway ( cd14, tlr4, myd88, tirap, ticam1, ticam2, irf-3, irf-5, ripk1, nf-kB , and ap-1 ). qPCR was performed using All-in-One qPCR Mix (GeneCopoeia) as previously described ( ).

    Techniques: Transfection, Expressing, Enzyme-linked Immunosorbent Assay, Flow Cytometry, Fluorescence